The monoamine oxidase (MAO) activity with tryptamine, 5-hydroxytryptamine and noreponephrine as substrates was studied as affected by different conditions of hyperbaric oxygenation. Exposure of rats to oxygenation at 1 ati resulted in a 75% activation of the brain mitochondria. MAO activity with norepinephrine and in an insignificant increase in the activity with the other substrates. Oxygenation at 2,4 and 6 ati decreased the brain MAO activity with all the substrates. The reduciton in the activity correlated with oxygen tension increase and with exposure time. The MAO 100% inhibition observed in some animals at 4 ati and ain most animals at 6 ati. In the liver the activity changes to a less extent than in the brain. At 1 ati it is somewhat increased and at 2, 4 and 6 ati it decreases.
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