[Free radical mechanisms of radiation modification of DNA sugar fragment].

Radiats Biol Radioecol

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow.

Published: June 1998

Analysis of the DNA and modeling its certain fragments substances radiolysis data allows to attribute the cardinal role to the primary 2-deoxyribosyl radicals in the processes of the breaks (C'3, C'5) and alkali-labile sites (C'1, C'2, C'4) in DNA strands, of the free bases appearance (C'3, C'5). The higher yield of bases destruction in DNA is explained by the transferring of a damage (unpaired electron) from 2-deoxyribosyl to a base within one nucleotide.

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