The behaviour of partial tensions of respiratory gases and pH in the arterial blood was evaluated in anoxiaemic and hypercapnic (1st group) and hypo-eucapnic (IInd group) subjects undergoing oxygen therapy. The following phenomena were observed: 1) normalization in paO2 values in both groups; 2) statistically significant diminution in paCO2, especially as regards hypercapnic subjects; 3) statistically significant diminution in blood pH; 4) statistically significant diminution in bicarbonates. In the light of these findings, it is considered that other variables, such as the electrolytes, might play an important role in pH diminution during oxygen therapy and that further research should be carried out to look into the possibility.
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In Vivo
December 2024
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, U.K.
Background/aim: Pharmacotherapy is vital in medicine, but inappropriate and inadequate use of medications significantly impacts global mortality and morbidity. Increased prescribing may indicate irrational use or prolonged illness, while decreased prescribing could suggest undertreatment, supply shortages, or the availability of safer and, more effective treatments. The COVID-19 pandemic disrupted health systems, potentially altering prescribing patterns.
View Article and Find Full Text PDFJ Nanobiotechnology
December 2024
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Ciudad de Mexico, Mexico.
Diabetes mellitus (DM) prevalence is rising worldwide. Current therapies comprising subcutaneous insulin injections can cause adverse effects such as lipodystrophy, local reactions like redness and swelling, fluid retention, and allergic reactions. Nanoparticle carriers for oral insulin are groundbreaking compared to existing methods because they are non-invasive treatments, showing operational convenience, controlled release profile, and ability to simulate the physiological delivery route into the bloodstream.
View Article and Find Full Text PDFJ Environ Sci (China)
May 2025
School of Environment, Nanjing Normal University, Nanjing 210023, China.
In the context of the prevalent winter air quality issues in China marked by declining PM and rising O, this study employed a modified WRF-Chem model to examine the aerosol radiation interaction (ARI), heterogeneous chemistry (AHC), and their combined impact (ALL) on the variations in O and PM during the 2014-2020 in eastern China. Our analysis confirmed that ARI curtailed O while elevating PM. AHC reduced O through heterogeneous absorption of NO and hydroxides while notably fostering fine-grained sulfate, resulting in a PM increase.
View Article and Find Full Text PDFBackground: sarcopenia, typified by the progressive diminution of skeletal muscle mass and functionality, represents a substantial public health challenge, particularly among the geriatric population. Dietary intake, as a modifiable determinant, has elicited considerable interest due to its prospective role in preventing and alleviating sarcopenia.
Methods: this investigation employed Mendelian randomization (MR) analysis, a robust statistical method, to investigate the causal associations between dietary consumption and sarcopenia-associated phenotypes, including appendicular lean mass (ALM), hand grip strength, and walking pace.
Int J Pediatr Otorhinolaryngol
November 2024
Department of Otolaryngology and Head and Neck Surgery, Shaare-Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel. Electronic address:
Objective: Tonsillar surgery is a common intervention for pediatric obstructive sleep apnea and recurrent tonsillitis. This study compared postoperative bleeding incidence and severity following tonsillotomy and tonsillectomy at a single medical center.
Study Design: A retrospective cohort study on 1984 pediatric patients (1-18 years old) who underwent surgery during 2004-2011 and 2019-2022.
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