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Does cytochrome 2D6 genotype affect the analgesic efficacy of codeine after ambulatory surgery? Prospective trial in 987 adults.
Acta Anaesthesiol Scand
January 2025
Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Perioperative and Intensive Care, Helsinki University Hospital, Helsinki, Finland.
Background: Paracetamol-codeine combination tablet is widely used in pain management after day surgery. For safety reasons, its use has decreased in recent years. Codeine is a prodrug metabolised in the liver by the cytochrome P450 2D6 (CYP2D6) enzyme to morphine that produces the analgesic effect of codeine.
View Article and Find Full Text PDFErrors associated with co-names of medicines: The nomenclature of combination medicinal products.
Br J Clin Pharmacol
November 2024
Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
In comparison to the efforts required to bring a new drug or formulation to the clinic, bestowing a name on a medicine is relatively simple. However, if the name we choose causes confusion-by making its contents ambiguous or if it is too alike another drug-it can precipitate clinical errors. This prompted the World Health Organization to set up the International Nonproprietary Naming Committee in the 1970s to select unambiguous names for drugs.
View Article and Find Full Text PDFPredictive Factors for 30-Day Readmission and Increased Healthcare Utilization in Sickle Cell Disease Patients: A Single-Center Comparative Retrospective Study.
Int J Gen Med
May 2024
Department of Medicine, College of Medicine, King Saud University (KSU) and King Saud University Medical City (KSUMC), Riyadh, Saudi Arabia.
Background: SCD poses a significant healthcare burden. Understanding the factors contributing to high healthcare utilization and readmissions is crucial for improving the quality of care provided.
Methods: This retrospective comparative observational study was conducted at King Saud University Medical City and included 160 SCD patients.
Two-year Opioid Prescription Trends in Local Sanitary Agency Naples 3 South, Campania Region, Italy. Descriptive Analyses and AI-based Translational Perspectives.
Transl Med UniSa
February 2024
Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Salerno, Italy.
Aims: This study delves into the two-year opioid prescription trends in the Local Sanitary Agency Naples 3 South, Campania Region, Italy. The research aims to elucidate prescribing patterns, demographics, and dosage categories within a population representing 1.7% of the national total.
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