Brainiac and fringe are similar pioneer proteins that impart specificity to notch signaling during Drosophila development.

Cold Spring Harb Symp Quant Biol

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Published: August 1998

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The Drosophila genes fringe and brainiac exhibit sequence similarities to glycosyltransferases. Drosophila and mammalian fringe homologs encode UDP-N-acetylglucosamine:fucose-O-Ser beta1,3-N-acetylglucosaminyltransferases that modulate the function of Notch family receptors. The biological function of brainiac is less well understood.

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