Two olfactory marker proteins in Xenopus laevis.

J Comp Neurol

University Stuttgart-Hohenheim, Institute of Physiology, Stuttgart, Germany.

Published: June 1998

Mature olfactory receptor neurons of mammals are characterized by the expression of the highly conserved olfactory marker protein (OMP) encoded by single copy genes. In Xenopus laevis, two homologous genes encoding olfactory marker proteins have been identified that share a sequence identity with mammalian OMPs of about 50%. Sequence comparison revealed significant variability in the N-terminus and C-terminus regions; in contrast, two internal domains were highly conserved between amphibian and mammalian OMPs, suggesting some functional relevance. The two OMP subtypes were regionally expressed in the olfactory nasal epithelium of Xenopus. XOMP1 transcripts were more abundant in the lateral diverticulum and XOMP2 in the medial diverticulum. The lateral location of XOMP1 and medial location of XOMP2 correspond to the suggested locations of olfactory receptor neurons responsive to water-borne and air-borne odorants, respectively.

Download full-text PDF

Source

Publication Analysis

Top Keywords

olfactory marker
12
marker proteins
8
xenopus laevis
8
olfactory receptor
8
receptor neurons
8
highly conserved
8
mammalian omps
8
olfactory
6
proteins xenopus
4
laevis mature
4

Similar Publications

Dominance hierarchies are key to social organization in group-living species, requiring individuals to recognize their own and others' ranks. This is particularly complex for intermediate-ranking animals, who navigate interactions with higher- and lower-ranking individuals. Using in situ hybridization, we examined how the brains of intermediate-ranked mice in hierarchies respond to dominant and subordinate stimuli by labeling activity-induced immediate early genes and neuronal markers.

View Article and Find Full Text PDF

Introduction The COVID-19 pandemic originated in Wuhan, China, and swiftly spread across all continents. The respiratory system is the most affected in people who acquire sickness as a result of SARS-CoV-2. However, the virus can also affect other systems.

View Article and Find Full Text PDF

Introduction: This study aims to investigate the progressive impact of chronic iron overload on the olfactory bulb, a region significantly affected in early neurodegenerative diseases like Parkinson's and Alzheimer's. The focus is on understanding how iron accumulation leads to oxidative stress, mitochondrial dysfunction, and neuronal damage over time in middle-aged mice.

Method: The mice were continuously administered FC for a duration of 16 weeks, and the olfactory behavior of the mice was observed at intervals of 4 weeks.

View Article and Find Full Text PDF

Olfaction is crucial to our dietary choices and significantly influences our emotional and cognitive landscapes. Understanding the underlying neural mechanisms is pivotal, especially through the use of electroencephalography (EEG). This technology has strong temporal resolution, allowing it to capture the dynamics of neural responses to odors, bypassing the need for subjective interpretations.

View Article and Find Full Text PDF

Type 2 biomarkers in olfactory cleft mucus correlate with SNOT-22 in chronic rhinosinusitis independent of nasal polyp status.

Int Forum Allergy Rhinol

December 2024

Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: Quantitative mucus cytokine analysis to examine the sinonasal microenvironment may bridge the gap between patient-reported outcome measures (PROMs) and empirical measures of inflammation in patients with chronic rhinosinusitis (CRS).

Objective: Investigate the correlation between mucus cytokine levels and Sino-Nasal Outcome Test (SNOT-22) scores, including individual subdomains.

Methods: Patients with CRS were prospectively recruited between 2016 and 2021 into a multi-institutional observational study.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!