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Predicting pain and its association with mortality in patients with stroke.
BMC Neurol
January 2025
Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenburg, Sweden.
Background And Objectives: Poststroke pain (PSP) is a prevalent and severe consequence of stroke, encompassing central, neuropathic, and nonneuropathic pain. In this study, we aimed to investigate clinical factors associated with PSP three months after stroke and concurrently explore the association between PSP and one-year mortality.
Methods: This registry-based study comprised data from stroke patients admitted to three hospitals in Sweden between November 2014 and June 2019.
Prediabetes and diabetes mellitus type II after ischemic stroke.
Eur Stroke J
January 2025
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Introduction: The progression of diabetes status in post-stroke patients remains under-investigated, particularly regarding new treatments for type II diabetes mellitus (DM II), like glucagon-like peptide 1 receptor agonists (GLP-1-RA) and sodium-glucose co-transporter-2 (SGLT-2) inhibitors, which have not been studied in the post-stroke setting.
Patients And Methods: Eight hundred eighty-four consecutive ischemic stroke patients recruited to our prospective STROKE-CARD Registry were assessed concerning their glycemic status at baseline (normoglycemia, prediabetes, DM II) and change over time within 1 year follow-up. Multivariate logistic regression was performed to identify factors associated with transitioning from normoglycemia to prediabetes or DM II.
G6PD protects against cerebral ischemia-reperfusion injury by inhibiting excessive mitophagy.
Life Sci
January 2025
Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. Electronic address:
Article Synopsis
- The study investigates the role of glucose-6-phosphate dehydrogenase (G6PD) in exacerbating brain damage caused by cerebral ischemia-reperfusion injury (CIRI) after a stroke.
- Researchers used various methods, including gene analysis and protein studies, to show that G6PD levels increase after ischemic events and that reducing G6PD leads to worsened brain damage and cell survival in models of ischemia.
- The findings suggest a significant link between G6PD and mitophagy, indicating that manipulating G6PD levels could help develop new treatments for brain damage resulting from strokes.
Adjunctive PCSK9 Inhibitor Evolocumab in the Prevention of Early Neurological Deterioration in Non-cardiogenic Acute Ischemic Stroke: A Multicenter, Prospective, Randomized, Open-Label, Clinical Trial.
CNS Drugs
January 2025
Department of Cardiology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Background: Early neurological deterioration (END) is associated with a poor prognosis in acute ischemic stroke (AIS). Effectively lowering low-density lipoprotein cholesterol (LDL-C) can improve the stability of atherosclerotic plaque and reduce post-stroke inflammation, which may be an effective means to lower the incidence of END. The objective of this study was to determine the preventive effects of evolocumab on END in patients with non-cardiogenic AIS.
View Article and Find Full Text PDFThalamic deep brain stimulation for central poststroke pain syndrome: an international multicenter study.
J Neurosurg
January 2025
1Department of Neurosurgery, Inselspital, Bern University Hospital, University Bern, Switzerland.
Objective: The effectiveness and optimal stimulation site of deep brain stimulation (DBS) for central poststroke pain (CPSP) remain elusive. The objective of this retrospective international multicenter study was to assess clinical as well as neuroimaging-based predictors of long-term outcomes after DBS for CPSP.
Methods: The authors analyzed patient-based clinical and neuroimaging data of previously published and unpublished cohorts from 6 international DBS centers.
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