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The Photocatalytic Activity of CaTiO Derived from the Microwave-Melting Heating Process of Blast Furnace Slag.
Nanomaterials (Basel)
April 2023
School of Resource and Environmental Engineering, Wuhan University of Science and Technology, Wuhan 430081, China.
The extraction of titanium-bearing components in the form of CaTiO is an efficient utilization of blast furnace slag. The photocatalytic performance of this obtained CaTiO (MM-CaTiO) as a catalyst for methylene blue (MB) degradation was evaluated in this study. The analyses indicated that the MM-CaTiO had a completed structure with a special length-diameter ratio.
View Article and Find Full Text PDFSupramolecular self-assembled AIE molecules are used in the search for target proteins in norcantharidin.
Anal Chim Acta
January 2023
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210002, People's Republic of China. Electronic address:
Norcantharidin (NCTD), a demethylated derivative of cantharidin, is an anticancer active component in traditional Chinese medicine. At present, the main methods for finding its target proteins are pharmacological methods and biophysical screening, which cannot achieve the purpose of efficient and accurate screening. Here we established a new analytical method for specific fishing and assisted imaging for norcantharidin target proteins.
View Article and Find Full Text PDFTranscriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
Sci Rep
April 2021
Leicester Cancer Research Centre, University of Leicester, Leicester, UK.
We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase (MTAP) deletion, seen frequently in malignant pleural mesothelioma (MPM). Here we show, that MTAP deletion is negatively prognostic in MPM. In vitro, the off-patent antibiotic Quinacrine efficiently suppressed PRMT5 transcription, causing chromatin remodelling with reduced global histone H4 symmetrical demethylation.
View Article and Find Full Text PDFBackground/aims: Aberrant activation of the Wnt/β-catenin signaling pathway plays a key role in the pathogenesis of multiple tumors including digestive cancers. Recent studies have reported that Dickkopf-related protein 2 (DKK2) is epigenetically inactivated in numerous types of cancers and that its gene products exhibit tumor-suppressive properties. However, the biological functions and underlying molecular mechanisms of DKK2 in colon carcinoma remains obscure.
View Article and Find Full Text PDFFunctional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression.
Oncogene
January 2017
University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA.
We have previously demonstrated that crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) facilitates breast cancer proliferation. However, the underlying mechanisms are largely unknown. Here, we report that expression of HDAC5 and LSD1 proteins were positively correlated in human breast cancer cell lines and tissue specimens of primary breast tumors.
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