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Serotonin release by parachloroamphetamine in rats with high and low sociability: High prefrontal release capacity in sociable females.
J Psychopharmacol
November 2024
School of Natural Sciences and Health, Tallinn University, Tallinn, Estonia.
Background: Social behaviour is the expression of one of the most generally accepted independent dimensions of personality. Serotonergic neurotransmission has been implicated in typical social response and drugs that promote serotonin (5-hydroxytryptamine (5-HT)) release have prosocial effects. By using the social interaction test, we have previously demonstrated sociability as a temperamental trait in male Wistar rats.
View Article and Find Full Text PDFPredicting health outcomes with intensive longitudinal data collected by mobile health devices: a functional principal component regression approach.
BMC Med Res Methodol
March 2024
School of Nursing, Duke University, Durham, USA.
Background: Intensive longitudinal data (ILD) collected in near real time by mobile health devices provide a new opportunity for monitoring chronic diseases, early disease risk prediction, and disease prevention in health research. Functional data analysis, specifically functional principal component analysis, has great potential to abstract trends in ILD but has not been used extensively in mobile health research.
Objective: To introduce functional principal component analysis (fPCA) and demonstrate its potential applicability in estimating trends in ILD collected by mobile heath devices, assessing longitudinal association between ILD and health outcomes, and predicting health outcomes.
Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters.
Neuropharmacology
December 2023
Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringer Strasse 13a, A-1090, Vienna, Austria; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan; Center for Addiction Research and Science - AddRess, Medical University of Vienna, Waehringer Strasse 13a, A-1090, Vienna, Austria. Electronic address:
Mephedrone (4-methylmethcathinone) is a cathinone derivative that is recreationally consumed for its energizing and empathogenic effects. The stimulating properties are believed to arise from the ability of mephedrone to interact with the high-affinity transporters for dopamine (DA) (DAT) and norepinephrine (NET), whereas the entactogenic effect presumably relies on its activity at the serotonin (5-HT) transporter (SERT). Early studies found that mephedrone acts as a releaser at NET, DAT and SERT, and thus promotes efflux of the respective monoamines.
View Article and Find Full Text PDFp-Chloroamphetamine decreases serotonin and induces apoptosis in granulosa cells and follicular atresia in prepubertal female rats.
Reprod Toxicol
June 2022
Laboratorio de Pubertad, Unidad Multidisciplinaria de Investigación, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, AP 9-020, C.P. 15000 Ciudad de México, Mexico. Electronic address:
Amphetamine derivatives negatively impact serotonin (5-HT) production, which triggers apoptosis in different tissues, depending on the receptor they bind. 5-HT in the ovary stimulates estradiol secretion, a survival factor of granulosa cells. The effect of amphetamine derivatives on the serotonergic system of the ovary and follicular development is unknown.
View Article and Find Full Text PDFSynthesis and biological evaluation of 1-(4-(piperazin-1-yl)phenyl)pyridin-2(1H)-one derivatives as potential SSRIs.
Eur J Med Chem
November 2021
Sunshine Lake Pharma Co. Ltd., Shenzhen, 518000, PR China; HEC Pharm Group, HEC Research and Development Center, Dongguan 523871, PR China. Electronic address:
A series of novel 1-(4-(piperazin-1-yl)phenyl)pyridin-2(1H)-one derivatives were synthesized and evaluated for their serotonin (5-HT) reuptake inhibitory activity. The results in vitro indicated that most of the evaluated compounds displayed potent 5-HT reuptake inhibition. The most promising compound A20 was stable in human liver microsomes and possessed good pharmacokinetic properties.
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