AI Article Synopsis
- The study examined how tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) are produced in patients with meningococcal disease.
- Both TNF and IL-1beta levels in the bloodstream returned to normal within 1 day, but their mRNA levels in white blood cells decreased over 3-4 days.
- While TNF production in stimulated blood cultures was down-regulated during the acute phase but restored later, IL-1beta production was also down-regulated, with this change linked to lower mRNA levels, indicating different regulatory mechanisms for these two cytokines.
Article Abstract
The regulation of tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) production was studied in patients with meningococcal disease. Circulating TNF and IL-1beta normalized within 1 day. TNF mRNA and IL-1beta mRNA in white blood cells decreased over 3-4 days. During the acute stage, TNF and IL-1beta production in stimulated whole blood cultures was down-regulated. After 4-5 days, this production was restored. The down-regulation was unlikely to be caused by circulating IL-6 and IL-10, as these cytokines normalized within 2-3 days. TNF mRNA in stimulated cultures during the acute stage, with down-regulated production, did not differ from that at recovery, with restored production. In contrast, the down-regulated production of IL-1beta was associated with significantly lower IL-1beta mRNA levels. Thus, TNF and IL-1beta production are differentially regulated. Whereas TNF production is regulated posttranscriptionally, IL-1beta production is also regulated at the mRNA level.
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| http://dx.doi.org/10.1086/517824 | DOI Listing |
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