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Breast surgery after neoadjuvant therapy.
Curr Opin Oncol
November 2022
Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Purpose Of Review: The standard of care in breast surgery has changed, from mastectomy to breast conserving surgery whenever possible, and from axillary dissection to sentinel node biopsy. Neoadjuvant systemic approaches have broadened the indications for organ-conserving and less mutilating surgery, but also raise important questions of balancing locoregional treatment de-escalation and protecting excellent long-term outcomes.
Recent Findings: Recent studies have aimed at investigating the safety of de-escalating surgical approaches not only in the upfront breast surgery situation but also after neoadjuvant systemic therapy.
Oncological outcomes in the management of cT1-T2 cN0 penile squamous cell carcinoma.
Can Urol Assoc J
June 2021
University of Toronto, Toronto, ON, Canada.
Introduction: Squamous cell carcinoma (SCC) of the penis is a rare disease comprising 1% of all male cancer. Options for the management of cT1-T2 cN0 penile SCC include partial penectomy (PP), considered the standard, and brachytherapy (BT), which offers acceptable local disease control and organ preservation. The purpose of our study was to assess and describe the oncological outcome for both treatments in a tertiary care center.
View Article and Find Full Text PDFMRI cT1-2 rectal cancer staging accuracy: a population-based study.
Br J Surg
September 2020
Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, VU University, Amsterdam, the Netherlands.
Background: Adequate MRI-based staging of early rectal cancers is essential for decision-making in an era of organ-conserving treatment approaches. The aim of this population-based study was to determine the accuracy of routine daily MRI staging of early rectal cancer, whether or not combined with endorectal ultrasonography (ERUS).
Methods: Patients with cT1-2 rectal cancer who underwent local excision or total mesorectal excision (TME) without downsizing (chemo)radiotherapy between 1 January 2011 and 31 December 2018 were selected from the Dutch ColoRectal Audit.
Multimodal Endoscopic Assessment Guides Treatment Decisions for Rectal Early Neoplastic Tumors.
Dis Colon Rectum
March 2020
Department of Colorectal Surgery, King's College Hospital National Health Service Foundation Trust, London, United Kingdom.
Background: There is a trend toward organ conservation in the management of rectal tumors. However, there is no consensus on standardized investigations to guide treatment.
Objective: We report the value of multimodal endoscopic assessment (white light, magnification chromoendoscopy and narrow band imaging, selected colonoscopic ultrasound) for rectal early neoplastic tumors to inform treatment decisions.
Immunomodulatory effects and potential clinical applications of dimethyl sulfoxide.
Immunobiology
May 2020
Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan. Electronic address:
Dimethyl sulfoxide (DMSO) was discovered during the 19th century by the German chemical industry. DMSO comprises a highly polar group and two non-polar domains, which render it soluble in both aqueous solutions and organic solutions. Furthermore, DMSO can penetrate the cell membrane of both the mammalian cells and the non-mammalian cells and prevent freeze-thaw injuries to the cells.
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