Changes in the biochemical composition of synaptosomal plasma membranes (SPM) isolated from mouse brains have been measured. The protein, phospholipid, and cholesterol contents all increased over the first 30 days of postnatal life, with the cholesterol to phospholipid molar ratio (one of the major determinants of lipid fluidity) also increasing in direct relation to the decrease in lipid fluidity. The fatty acid composition of SPM also changes with the increase in 18:0, and the decrease in 18:2, 18:3, and 22:4, in keeping with the increase in membrane order. Steroid hormones alter lipid fluidity to a greater degree in fluid membranes, indicating that the nongenomic effects of steroids will be most prevalent in membranes during the early prenatal period and for the first days following birth. The potential effects of xenobiotics on membrane fluidity are also discussed.
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