Unlabelled: A total of 3,787 electrocardiograms were obtained with transtelephonic monitors (TT-ECG) during 1994 in CardioTel of Central America, Nueva San Salvador, El Salvador. Each case was evaluated in terms of patient's risk and classified as high or low risk on basis of its clinical profile. There were 3,441 traces of low risk patients and 346 of high risk one. Female patients accounts for 64.7% of cases, with 35.3% corresponding to males. Of all the TT-ECG's a 52.3% were normal. Subjects older than 60 years (independently of risk had a greater probability of an abnormal TT-ECG; in the same way there was an statistically significative increase in the incidence of abnormal TT-ECG in high risk subjects compared with low risk ones. In respect to specific TT-ECG abnormalities against cardiovascular risk, a high risk condition implied a greater incidence of bundle branch blocks, signs of myocardial lesion/necrosis, left ventricular hypertrophy, sinus tachycardia and bradycardia, atrial fibrillation and premature ventricular and supraventricular complexes, with a p value of 0.05 of 0.001.
Conclusions: TT-ECG is useful in the search of cardiovascular disease, regardless the presence or absence of symptoms. Age greater than 60 years and high cardiovascular risk implies a greater probability of abnormal TT-ECG.
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Arterioscler Thromb Vasc Biol
January 2025
Cardiovascular Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. (A.S., R.M.F., F.M.v.H.).
Background: Binding of ANGPTL (angiopoietin-like protein)-3 to ANGPTL8 generates a protein complex (ANGPTL3/8) that strongly inhibits LPL (lipoprotein lipase) activity, as compared with ANGPTL3 alone, suggesting that ANGPTL3/8 concentrations are critical for the regulation of circulation lipoprotein concentrations and subsequent increased coronary heart disease (CHD) risk. To test this hypothesis in humans, we evaluated the associations of circulating free ANGPTL3 and ANGPTL3/8 complex concentrations with lipoprotein concentrations and CHD risk in 2 prospective cohort studies.
Methods: Fasting blood samples were obtained in conjunction with the baseline evaluation of 9479 subjects from 2 population-based Swedish cohorts of middle-aged men and women.
Curr Med Res Opin
January 2025
Section of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.
Introduction: The management of patients with Polycythemia Vera (PV) traditionally includes low-dose aspirin, phlebotomy, and cytoreductive therapy for high-risk individuals. Recent evidence suggests that cytoreductive treatment may be warranted for patients with additional risk factors beyond the traditional criteria of a history of thrombosis and age over 60 years. Introducing new therapeutic agents, including ropeginterferon alfa-2b and ruxolitinib, enables a more personalized treatment approach tailored to individual patient characteristics.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Department of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit. Many studies have reported that people with AV have higher levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) compared to healthy controls. Hence, they concluded that an unhealthy lipid profile is an independent risk factor for AV.
View Article and Find Full Text PDFBull World Health Organ
February 2025
Department of Global Health, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing100191, China.
Objective: To conduct a systematic review and meta-analysis of the facilitators of and barriers to the acceptance and use of digital health technology by health workers in low- and middle-income countries.
Methods: We searched several databases for relevant articles published until 25 April 2024. We extracted data on four unified theories of acceptance and use of technology factors (performance expectancy, effort expectancy, social influence and facilitating conditions) and six additional factors (attitude, habit, incentive, risk, trust and self-efficacy); how these affected the outcomes of behavioural intention and actual use; and the strength of association if reported.
Heliyon
January 2025
Department of Chemistry, Faculty of Science, University of Dhaka, Dhaka, 1000, Bangladesh.
This study investigated the ramifications of black carbon (BC) emissions on human health during the winter season of December 2019 to February 2020 in Dhaka, Bangladesh. BC, arising from incomplete combustion of fossil and biofuels, underwent meticulous measurement of densities, concentrations, and emissions at two pivotal sites. Employing low-volume air samplers with Quartz filters and subsequent analysis with an Aethalometer (Soot scanner, OT21, USA), the study unveiled monthly average BC densities of 1.
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