Spontaneous dissecting aneurysm of coronary artery in a pregnant woman at term.

Pathol Res Pract

Institute of Anatomic Pathology and Histology, University of Perugia, Italy.

Published: July 1998

AI Article Synopsis

  • A case study presents a 44-year-old pregnant woman with no prior vascular risk factors who developed a spontaneous dissecting aneurysm in her circumflex coronary artery.
  • Spontaneous coronary artery dissection is rare, particularly affecting women, especially in the postpartum period, with the left anterior descending artery being the most commonly involved.
  • Theories explaining this condition during pregnancy include arterial wall changes, hemodynamic factors, and contributions from immune cells leading to injury in the arterial wall.

Article Abstract

We describe a case of spontaneous dissecting aneurysm of the circumflex coronary artery in a 44-year-old primigravida at term with no vascular risk factors. Spontaneous coronary artery dissection is a very rare condition with a greater prevalence in women, postpartum in particular. The left anterior descending artery is the most frequently affected. Histologically, the most common finding is a hematoma occupying the outer third of the media, resulting in complete compression of the true lumen. Arterial wall changes during pregnancy together with hemodynamic factors, a lytic action of protease released from eosinophils, and intimal tears are the main hypotheses considered to explain the etiology of spontaneous coronary artery dissection.

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Source
http://dx.doi.org/10.1016/S0344-0338(98)80081-2DOI Listing

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