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Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022.
Animals (Basel)
December 2024
Department of Avian Diseases, College of Veterinary Medicine and Center for Avian Disease, Jeonbuk National University, Iksan 54596, Republic of Korea.
Duck circovirus (DuCV) infections cause immunosuppression in ducks, potentially leading to significant economic losses for the duck farming industry. This study investigates the prevalence, genetic characteristics, and evolutionary trends of DuCV in Korea between 2013 and 2022. Samples from 184 farms across seven provinces were analyzed using polymerase chain reaction (PCR).
View Article and Find Full Text PDFPotential role of heteroplasmic mitochondrial DNA mutations in modulating the subtype-specific adaptation of oral squamous cell carcinoma to cisplatin therapy.
Discov Oncol
October 2024
Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Article Synopsis
- Cancer cells evolve to resist drug treatments, specifically examining how mitochondrial DNA (mtDNA) changes contribute to resistance in oral squamous cell carcinoma (OSCC) against cisplatin.
- The study generated cisplatin-resistant OSCC cell lines and analyzed changes in mtDNA using sequencing and other techniques, revealing mutations and altered methylation patterns.
- Findings suggest that specific mtDNA alterations, influenced by the cancer's genetic background, are key to understanding and potentially overcoming cisplatin resistance, highlighting the importance of personalized treatment strategies for OSCC patients.
Article Synopsis
- - Since 2013, there have been 167 cases of people infected with special flu viruses from pigs in the U.S. called swine-origin influenza A.
- - Most of these viruses had a change in their genes that makes them resistant to certain medicines, but none were resistant to another type of medicine called neuraminidase inhibitors.
- - Scientists did tests to find out how well these viruses respond to treatments and discovered that one specific change in the virus made it much harder to treat with a medicine called baloxavir.
Lipid droplets: a candidate new research field for epithelial ovarian cancer.
Front Pharmacol
July 2024
Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.
Ovarian clear cell carcinoma (OCCC) is a histological subtype that constitutes approximately 20% of epithelial ovarian cancer cases in Asian countries, but has a relatively low incidence in Western countries. Meanwhile, clear cell renal cell carcinoma (ccRCC) is a major subtype of kidney cancer. OCCC and ccRCC resemble one another histologically and have clear cytoplasmic appearances.
View Article and Find Full Text PDFInfluenza A defective viral genome production is altered by metabolites, metabolic signaling molecules, and cyanobacteria extracts.
bioRxiv
July 2024
Department of Microbiology and Molecular Genetics University of California, Davis One Shields Ave Davis CA 95616.
RNA virus infections are composed of a diverse mix of viral genomes that arise from low fidelity in replication within cells. The interactions between "defective" and full-length viral genomes have been shown to shape pathogenesis, leading to intense research into employing these to develop novel antivirals. In particular, Influenza A defective viral genomes (DVGs) have been associated with milder clinical outcomes.
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