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EXtending Omalizumab Treatment Intervals in patients with Chronic spontaneous urticaria (EXOTIC): protocol of a multicentre, randomised, open-label, non-inferiority trial.
BMJ Open
January 2025
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Introduction: Omalizumab, an anti-IgE monoclonal antibody, is effective in treating antihistamine-refractory chronic spontaneous urticaria (CSU). However, tapering strategies for omalizumab are currently not well-studied, and patients may be treated longer than needed. Here, we present the rationale and design of the EXtending Omalizumab Treatment Intervals in patients with Chronic spontaneous urticaria trial, a multicentre, randomised, open-label, non-inferiority clinical trial.
View Article and Find Full Text PDFTreatment of Gastrointestinal Infectious Diseases in Exotic Animals.
Vet Clin North Am Exot Anim Pract
December 2024
Zoological Medicine Service, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, 2065 W. Farm Road, Stillwater, OK 74078, USA. Electronic address:
Antimicrobials should be used judiciously when managing gastrointestinal disorders in exotic animals. Oral administration of antibiotics targeting gram-positive flora must be avoided in hindgut fermenters. Immunosuppressives may be indicated for certain infectious diseases, such as chronic enteric coronavirus in ferrets and avian ganglioneuritis in parrots.
View Article and Find Full Text PDFAre the Effects of Bioactive Components on Human Health a Myth?: Black Elderberry (Sambucus nigra L.) from Exotic Fruits.
Curr Nutr Rep
December 2024
Department of Nutrition and Dietetics, School of Health Sciences, Ankara Medipol University, 06050, Altındağ, Ankara, Turkey.
Purpose Of Review: Black elderberry has come to the fore in recent years due to its health benefits. Black elderberry fruit (Sambucus nigra L.), collected from natural sources, has a rich content of protein, vitamins, antioxidants, unsaturated fatty acids, and minerals as it contains conjugated and free forms of amino acids.
View Article and Find Full Text PDFThe Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats.
Cancers (Basel)
June 2024
Department of Epizootiology and Clinic of Birds and Exotic Animals, Division of Infectious Diseases and Veterinary Administration, The Faculty of Veterinary Medicine in Wroclaw, Wrocław University of Environmental and Life Sciences, Grunwaldzki Sq. 45, 50-366 Wrocław, Poland.
Recent advancements have significantly enhanced our understanding of the crucial role animal microbiomes play in veterinary medicine. Their importance in the complex intestinal environment spans immune modulation, metabolic homeostasis, and the pathogenesis of chronic diseases. Dysbiosis, a microbial imbalance, can lead to a range of diseases affecting both individual organs and the entire organism.
View Article and Find Full Text PDFThis case report describes the effects of fecal microbiota transplantation (FMT) administered via enema in a 4-year-old spayed, champagne Domestic Ferret () with chronic diarrhea, maldigestion and weight loss. We aimed to establish a protocol for FMT as a novel therapeutic treatment for chronic diarrhea in domestic ferrets. We mapped the fecal microbiome by 16S rRNA gene amplicon sequencing to track the patient's fecal microbiota throughout the treatment and observation period.
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