Sequencing DNA using mass spectrometry for ladder detection.

Nucleic Acids Res

Life Science Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6378, USA andYale University Medical Center, New Haven, CT, USA.

Published: May 1998

Sequencing of DNA fragments of 130 and 200 bp using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for DNA ladder detection was demonstrated. With further improvement in mass resolution and detection sensitivity, mass spectrometry shows great promise for routine DNA sequencing in the future.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC147544PMC
http://dx.doi.org/10.1093/nar/26.10.2488DOI Listing

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