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The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus.
Cell Mol Immunol
November 2024
Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Article Synopsis
- Inflammasomes are key in fighting infections, and the study focuses on how HSV-1, a contagious virus, uniquely interacts with the host's immune response.
- The researchers discovered that a gene called TET3 is critical for HSV-1 infection, as it helps activate a specific inflammasome in the nucleus by binding to caspase-1.
- Blocking TET3’s interactions can hinder the virus’s ability to spread, suggesting potential new treatments for HSV-1 infections in the future.
Effect of pioglitazone on inflammatory response and clinical outcome in T2DM patients with COVID-19: a randomized multicenter double-blind clinical trial.
Front Immunol
September 2024
Medicine Department, Hamad Medical Corporation, Doha, Qatar.
Article Synopsis
- COVID-19 poses a higher mortality risk for individuals with diabetes, severe obesity, and cardiovascular disease, potentially due to chronic inflammation linked to type 2 diabetes.
- This study involved 350 patients with type 2 diabetes hospitalized for moderate-severe COVID-19, comparing the effects of pioglitazone against a placebo over 28 days, focusing on severe clinical outcomes and inflammation levels.
- Although pioglitazone reduced certain inflammatory markers, it did not significantly improve outcomes, as more patients treated with it required ICU care and showed no notable difference in CRP reduction compared to those on placebo.
Long-Term Interplay Between SARS-CoV-2 and Renal Impairment.
Cureus
August 2024
Department of Physiology, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
Introduction The SARS-CoV-2 virus causes the highly contagious coronavirus disease 2019 (COVID-19), which most commonly manifests as severe acute respiratory syndrome. The virus is part of the Coronaroviridae family, a group of viruses that can cause various diseases, such as the common cold, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). The World Health Organization (WHO) declared the outbreak of COVID-19 as a pandemic on March 11, 2020.
View Article and Find Full Text PDFInvestigating SARS-CoV-2 virus-host interactions and mRNA expression: Insights using three models of D. melanogaster.
Biochim Biophys Acta Mol Basis Dis
October 2024
Laboratory of Experimental Biochemistry and Toxicology, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil; Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil. Electronic address:
Responsible for COVID-19, SARS-CoV-2 is a coronavirus in which contagious variants continue to appear. Therefore, some population groups have demonstrated greater susceptibility to contagion and disease progression. For these reasons, several researchers have been studying the SARS-CoV-2/human interactome to understand the pathophysiology of COVID-19 and develop new pharmacological strategies.
View Article and Find Full Text PDFApplication and internal validation of lung ultrasound score in COVID-19 setting: The ECOVITA observational study.
Pulmonology
May 2024
Department of Precision Medicine, University of Campania L. Vanvitelli, Naples, Italy.
Background: The severe acute respiratory syndrome Coronarovirus-2 associated still causes a significant number of deaths and hospitalizations mainly by the development of respiratory failure. We aim to validate lung ultrasound score in order to predict mortality and the severity of the clinical course related to the need of respiratory support.
Methods: In this prospective multicenter hospital-based cohort study, all adult patients with diagnosis of SARS-CoV-2 infection, performed by real-time reverse transcription polymerase chain reaction were included.
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