The antiviral activity of iodantipyrine was studied in outbred [correction of inbred] albino mice (weight 10-12 g) infected with the Absettarov strain of the tick-borne encephalitis virus. Iodantipyrine was administered per os or parenterally and the animals were observed for 21 days. A reliable therapeutic effect was produced in 60% of mice infected with 10 DL50 of tick-borne encephalitis virus which were given the drug per os in a dose of 50 mg/kg. Preventive administration of the drug was effective in 47% of the animals.
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Whole-genome sequencing surveillance of Siberian tick-borne encephalitis virus (TBEV) identifies an additional lineage in Kyrgyzstan.
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Article Synopsis
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