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Chapter 4: DIFFERENTIAL DIAGNOSIS of PRIMARY HYPERPARATHYROIDISM.
Ann Endocrinol (Paris)
January 2025
Service d'Endocrinologie, Diabétologie, Métabolisme, Nutrition; Hôpital Huriez, CHU Lille; Inserm U1190, Institut Génomique Européen pour le Diabète, Université de Lille, F-59000 Lille, France. Electronic address:
The differential diagnosis of primary hyperparathyroidism can be considered clinically, biologically and radiologically. Clinically, primary hyperparathyroidism should be suspected in case of diffuse pain, renal lithiasis, osteoporosis, repeated fracture, cognitive or psychiatric disorder, or disturbance of consciousness. Nevertheless, the differential diagnosis of primary hyperparathyroidism is mainly biological, particularly in atypical forms, which must be differentiated from hypercalcemia with hypocalciuria or non- elevated PTH on the one hand, and from normo-calcemia with elevated PTH, hypophosphatemia or hypercalciuria on the other.
View Article and Find Full Text PDFInsulin Resistance in Hypercalciuric Calcium Kidney Stone Patients.
Kidney Med
December 2024
Department of Medicine, University of Chicago, Chicago IL.
Rational & Objective: Diabetes and uric acid kidney stones are strongly associated. Patients with calcium kidney stones also have higher risk of developing diabetes compared with nonkidney stone patients yet this has not been further investigated. We aimed to characterize insulin resistance in calcium kidney stone patients.
View Article and Find Full Text PDFPediatric hypoparathyroidism: etiological and clinical evaluation in a tertiary center.
Endocrine
November 2024
Department of Pediatric Endocrinology, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.
Purpose: This study aims to evaluate the etiology, clinical presentation, and management of pediatric hypoparathyroidism in a tertiary center.
Methods: A retrospective review was conducted on pediatric patients diagnosed with hypoparathyroidism at the Pediatric Endocrinology Clinic from March 2021 to June 2023. Data on demographic characteristics, presenting symptoms, laboratory findings, genetic analyses, and treatment outcomes were collected.
A narrative review of monogenic disorders causing nephrolithiasis and chronic kidney disease.
Nephrology (Carlton)
December 2024
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- - The incidence of genetic diseases linked to chronic kidney disease (CKD) has been on the rise, prompting a review of monogenic causes related to kidney stone disorders.
- - Identified monogenic conditions include primary hyperoxaluria, cystinuria, and Dent disease, all of which can lead to CKD and possibly progress to end-stage kidney disease (ESKD).
- - It's important to conduct genetic testing in children with kidney stones, as a significant number of these patients may develop CKD due to underlying genetic disorders.
miR-148b-5p regulates hypercalciuria and calcium-containing nephrolithiasis.
Cell Mol Life Sci
August 2024
Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510230, Guangdong, China.
Article Synopsis
- Calcium-containing kidney stones are the most common type and are often associated with idiopathic hypercalciuria, though their exact causes are still unclear.
- This study investigated the role of a specific microRNA, miR-148b-5p, found in urinary exosomes, which was linked to increased urinary calcium levels and stone formation in both rat models and human samples.
- The research indicates that miR-148b-5p lowers the expression of the calcitonin receptor (Calcr), playing a crucial role in regulating calcium excretion and kidney stone formation, and suggests that targeting this microRNA could lead to new treatments for this condition.
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