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The role of fear and dopamine-striatal pathways in grooming.
Neuropharmacology
January 2025
School of Psychological Sciences, The University of Haifa, Haifa, Israel; The Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel. Electronic address:
Fear is a fundamental emotion that triggers rapid and automatic behavioral response. Fear is known to suppress reward-seeking behaviors, interrupt previous activities to prioritize defensive responses and lead to rapid switch to defensive reactions. Dopamine (DA) plays a complicated role in the choice and performance of actions and it has a potential interaction of innate actions with the presence of fear.
View Article and Find Full Text PDFFormulation screening of lyophilized mRNA-lipid nanoparticles.
Int J Pharm
January 2025
Department of Pharmaceutics, Institute of Pharmaceutical Sciences, University of Freiburg, Sonnenstr. 5, Freiburg i. Br. 79104 Germany; ten23 health AG, Mattenstr. 22, Basel 4058 Switzerland. Electronic address:
Lipid nanoparticles (LNPs) have demonstrated their therapeutic potential as safe and effective drug delivery systems for nucleic acids during the COVID-19 pandemic. However, one of the main challenges during technical CMC (Chemistry, Manufacturing, and Controls) development is their long-term stability at temperatures of 2-8 °C or higher, which may be improved by the removal of water by lyophilization. In this study, we identified lyo-/cryo-protectants for freeze-dried mRNA-LNP formulations beyond conventional excipients such as sucrose and trehalose as T-modifiers using polyA as a surrogate.
View Article and Find Full Text PDFProbing the magnetic ground state of stretched diamond lattices NdTaO4 and NdNbO4: Impact of spin-orbit coupling and crystal electric field.
J Phys Condens Matter
January 2025
School of Physical Sciences, Indian Institute of Technology Mandi, Mandi, Mandi, Himachal Pradesh, 175075, INDIA.
Magnetic systems, wherein competing degree of freedoms arising from spin orbit coupling and crystal electric field lead to non-trivial magnetic ground states, remains in the forefront of research in condensed matter physics. Here, we present a comprehensive investigation on three-dimensional rare-earth based spin systems NdTaO4 and NdNbO4, where the Nd ions sit on a stretched diamond lattice. No signatures of long-range ordering and spin freezing are observed down to 1.
View Article and Find Full Text PDFCryopreserved Umbilical Cord Mesenchymal Stem Cells Show Comparable Effects to Un-Cryopreserved Cells in Treating Osteoarthritis.
Cell Transplant
January 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Non-cryo and hypothermic preservations are two available options for short-term storage of living cells. For long-term cell storage, cryopreservation is an essential procedure as it prolongs the storage time, allowing for the transport and testing of cells, as well as the establishment of cell banks. But it is unclear whether cryopreservation reduces the therapeutic effects of human umbilical cord mesenchymal stem cells (hucMSCs) on osteoarthritis (OA).
View Article and Find Full Text PDFNavigating the practical challenges and ethical dilemmas of surplus cryopreserved human embryos.
Syst Biol Reprod Med
December 2025
College of Medicine, Department of Basic Sciences, Roseman University of Health Sciences, Las Vegas, NV, USA.
Cryopreservation, the use of very low temperatures to preserve structurally intact living cells and tissues, has seen exponential growth in the field of fertilization (IVF). In the last decade, cryopreservation of embryos and freeze-all protocols have become an essential aspect and a prerequisite for a successful IVF outcome. Moreover, vitrification, which is a fast and safe cryopreservation method, has proved to be an effective choice for cryopreserving gametes and embryos.
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