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Prolonged storage reduces viability of and core intestinal bacteria in fecal microbiota transplantation preparations for dogs.
Front Microbiol
January 2025
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, United States.
Introduction: Fecal microbiota transplantation (FMT) has been described useful as an adjunct treatment for chronic enteropathy in dogs. Different protocols can be used to prepare and store FMT preparations, however, the effect of these methods on microbial viability is unknown. We aimed (1) to assess the viability of several core intestinal bacterial species by qPCR and (2) to assess () viability through culture to further characterize bacterial viability in different protocols for FMT preparations.
View Article and Find Full Text PDFIntrinsic and environmental drivers of pairwise cohesion in wild Canis social groups.
Ecology
January 2025
Wildlife Research and Monitoring Section, Ministry of Natural Resources and Forestry, Peterborough, Ontario, Canada.
Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group-level processes such as subgroup formation and fission-fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing cohesion remains a gap in our knowledge of cooperative behavior in animals.
View Article and Find Full Text PDFValue-based healthcare payment models: a wolf in sheep's clothing for patients and clinicians.
Ann Med
December 2024
MT State University, Bozeman, MT, USA.
Value-based healthcare payment models are an alternative insurance payment system that compensates healthcare providers based on their patients' outcomes rather than the individual services healthcare workers provide. This shift from the current fee-for-service model that predominates our medical system has received renewed popularity and attention within organized medicine such as the American Medical Association. Advocates believe that this new payment model will address many of the unsolved issues in healthcare such as medical waste and unsustainable healthcare costs.
View Article and Find Full Text PDFWhy is it so hard for academic medical centers to succeed in value-based care?
Health Aff Sch
July 2023
Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94117, United States.
Academic medical centers (AMCs) excel in many ways, but struggle to succeed at delivering cost-effective care in value-based payment models. To the extent these payment models become more widespread, or mandatory, this could be a giant risk to the future success of AMCs. Many attributes of AMCs that have served them well in a fee-for-service payment system may hinder the transformation needed to succeed in value-based care.
View Article and Find Full Text PDFImage-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer.
J Pathol
March 2024
UCD School of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples.
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