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Role of thromboxane TP and angiotensin AT1 receptors in lipopolysaccharide-induced arterial dysfunction in the rabbit: an in vivo study.
Eur J Pharmacol
May 2010
Division of Angiology, Servier Research Institute, 11 Rue des Moulineaux, 92150 Suresnes, France.
Inflammation plays a major role in pathological conditions leading to cardiovascular events. Administration of lipopolysaccharide to animals decreases arterial blood flow, in contrast to the dilatations that occur in microvessels. The purpose of the present study was to determine whether or not lipopolysaccharide, in vivo, evokes arterial constriction and if so the underlying mechanisms.
View Article and Find Full Text PDFAltered TP receptor function in isolated, perfused kidneys of nondiabetic and diabetic ApoE-deficient mice.
Am J Physiol Renal Physiol
January 2008
Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France.
Early manifestations of kidney disease occur in atherosclerosis and activation of TP (thromboxane A(2)) receptors is implicated in atherosclerotic, diabetes, and renal diseases. The purpose of the present study was to analyze, in isolated, perfused mouse kidneys, the participation of TP receptors in renal vasoconstrictions and vasodilatations. In kidneys, taken from wild-type C57BL6, apolipoprotein E-deficient (ApoE-KO) and diabetic ApoE-KO mice, changes in perfusion pressure were recorded.
View Article and Find Full Text PDF[Terutroban and endothelial TP receptors in atherogenesis].
Med Sci (Paris)
April 2006
Division d'Angiologie, Institut de Recherche Servier, 11, rue des Moulineaux, 92150 Suresnes, France.
Treatment of thrombotic diseases implicates the use of anti-platelet agents, anti-coagulants and pro-fibrinolytic substances. Amongst the anti-platelet drugs, aspirin occupies a unique position. As soon as it became evident that the major action of aspirin is indirect blockade, through inhibition of cyclooxygenase (COX), of the production of thromboxane A2 (TXA2), a powerful vasoconstrictor and platelet activator, research for new anti-thrombotics that interact more specifically with the production and/or the action of TXA2 was started.
View Article and Find Full Text PDFThromboxane A2/prostaglandin H2 receptor activation mediates angiotensin II-induced postischemic neovascularization.
Arterioscler Thromb Vasc Biol
March 2006
Cardiovascular Research Center INSERM U689 Lariboisière, Université Paris, Paris, France.
Objective: We analyzed the involvement of thromboxane (TX) A2/prostaglandin (PG) H2 (TP) receptor in ischemia-induced neovascularization in mice.
Methods And Results: Unilateral hindlimb ischemia was induced by right femoral artery ligature in male C57BL/6J mice (n=7 per group). Animals were then treated with or without TP receptor antagonist (S18886, 5 or 10 mg/kg per day; ramatroban, 10 mg/kg per day) or aspirin (30 mg/kg per day) in drinking water for 21 days.
Endothelium-dependent contractions to acetylcholine, ATP and the calcium ionophore A 23187 in aortas from spontaneously hypertensive and normotensive rats.
Fundam Clin Pharmacol
June 2004
First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
The present study was designed to determine whether or not an increase in endothelial intracellular concentration of calcium ([Ca2+]i) evokes endothelium-dependent contractions in the aorta from normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Acetylcholine, adenosine triphosphate (ATP) and the calcium ionophore, A 23187, produced endothelium-dependent relaxations in isolated aortic rings of both WKY and SHR. These relaxations in response to the three agonists were significantly smaller in the SHR when compared with the WKY.
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