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Similar Publications
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class.
Bioorg Med Chem Lett
April 1998
Research Department, Novartis Pharma AG, Basel, Switzerland.
The two geminal ethyl groups in the succinic acid moiety of CGP57698 (4-[3-(7-fluoro-2-quinolinyl-methoxy)phenyl-amino]-2,2-diethyl-4-oxo- butanoic acid) are responsible for the high in vitro and in vivo potency of this peptidoleukotriene antagonist of the quinoline type. The synthesis and structure activity relationships of CGP57698 and its analogs are described.
View Article and Find Full Text PDFCGP57698: a structurally simple, highly potent peptido-leukotriene (pLT) antagonist of the quinoline type.
Adv Exp Med Biol
June 1998
Novartis Pharma AG, Basel, Switzerland.
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