AI Article Synopsis
- Nerve growth factor (NGF) has been shown to inhibit the growth and progression of small-cell lung carcinoma (SCLC) cell lines, which are known for their aggressive nature.
- Chronic exposure to NGF not only reduces the proliferation of SCLC cells but also prevents their ability to grow independently in cultures, invade other tissues, and form tumors in animal models.
- Additionally, NGF treatment alters the SCLC cells' response to nicotine, effectively reverting them to a less invasive and non-tumorigenic state that continues to produce NGF.
Article Abstract
Nerve growth factor (NGF) has antiproliferative and differentiating effects on adenomas of neuroendocrine origin. Cell lines derived from small-cell lung carcinoma (SCLC), a very aggressive neuroendocrine tumor, express NGF receptors. The role of NGF in the control of proliferation and progression of this carcinoma, however, has never been investigated. Chronic exposure of NCI-N-592 and GLC8 SCLC cell lines to NGF remarkably inhibited their proliferation rate both in vitro and in vivo, prevented their anchorage-independent clonal growth in soft agar, impaired their invasive capacity in vitro, and abolished their tumorigenic potential in nude mice. The proliferative response of SCLC cell lines to nicotine was also remarkably impaired by in vitro NGF treatment. Furthermore, NGF treatment activates in SCLC cell lines the expression and secretion of NGF. NGF thus reverts SCLC cell lines to a noninvasive, nontumorigenic phenotype that does not respond to nicotine and produces NGF.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20267 | PMC |
| http://dx.doi.org/10.1073/pnas.95.9.5366 | DOI Listing |
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