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Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study.
Lancet Microbe
January 2025
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. Electronic address:
Background: Antibiotic heteroresistance is a common bacterial phenotype characterised by the presence of small resistant subpopulations within a susceptible population. During antibiotic exposure, these resistant subpopulations can be enriched and potentially lead to treatment failure. In this study, we examined the prevalence, misclassification, and clinical effect of heteroresistance in Escherichia coli bloodstream infections for the clinically important antibiotics cefotaxime, gentamicin, and piperacillin-tazobactam.
View Article and Find Full Text PDFInvestigation of the relationship between lead exposure in heavy metals mixtures and the prevalence of stroke: a cross-sectional study.
BMC Public Health
December 2024
Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Background: The adverse effects of environmental toxic metal exposure on human health are well-documented. However, the specific influence of heavy metal exposure on stroke prevalence remains underexplored.
Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018 to investigate the association between blood metal concentrations and the incidence of stroke.
"It's his cheerfulness that gives me hope": A qualitative analysis of access to pediatric cancer care in Northern Tanzania.
PLOS Glob Public Health
December 2024
Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America.
Pediatric cancer is a significant and growing burden in low- and middle-income countries. The objective of this project was to describe the factors influencing access to pediatric cancer care in Northern Tanzania using the Three Delays Model. This was a cross-sectional qualitative study conducted between June and August 2023 at Kilimanjaro Christian Medical Centre (KCMC).
View Article and Find Full Text PDFAssociation Between Weight-Adjusted Waist Index and Periodontitis: A Cross-Sectional Study and Mediation Analysis.
Diabetes Metab Syndr Obes
November 2024
Department of Endodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, People's Republic of China.
Aim: The research examined the correlation between the weight-adjusted waist index (WWI) and periodontal disease, as well as the intermediary influence of triglyceride glucose (TyG) index-related indicators, utilizing a health examination dataset.
Methods: This cross-sectional study included 39,522 subjects from health check-up database of Shanghai Health and Medical Center. The WWI was determined by applying a formula that includes dividing the waist circumference (WC) by the body weight's square root.
Oxidative stress and inflammatory factors mediate the association between dietary antioxidant intake and depressive symptoms in middle and old-aged individuals: A cross-sectional study from NHANES.
Gen Hosp Psychiatry
December 2024
Rehabilitation Medicine Department, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, The First Hospital of Changsha, Changsha, China. Electronic address:
Background: The relationship between dietary antioxidant intake and depression remains controversial. This study aimed to explore the intermediary role of oxidative stress and inflammatory markers in linking dietary antioxidant intake to depression among middle-aged and older adults.
Methods: This is a cross-sectional study from the 2003-2014 National Health and Nutrition Examination Survey (NHANES), depressive symptoms were identified using a score of 10 or above on the Patient Health Questionnaire-9 (PHQ-9).
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