In young healthy male adults, a decrease in the mechanical load of the ventilatory apparatus was followed by readjustment in the respiratory cycle. During hyperventilation due to an enhanced hypercapnic stimulus, a reduction of resistance against breathing tells on the value of ventilatory response, the latter being greater than when breathing with mixtures of ordinary density. The data obtained confirm the significance of value of the mechanical load of respiratory apparatus for formation of ventilatory response to hypoxia and hypercapnia.
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