A principal goal of this research was to conduct a field evaluation of "on-site" multi-analyte drug testing devices to determine the most accurate, efficient, and cost-effective device available for the purpose of rapidly detecting drivers under the influence of drugs. Four on-site kits were selected and evaluated for accuracy and efficiency for the detection of tetrahydrocannabinol (THC), the cocaine metabolites (COC), and opiates (OPI). From 16 December 1995 to 17 March 1996, 303 voluntary urine specimens were collected by law enforcement officers from persons arrested for driving-under-the-influence (DUI). These specimens were tested using the four selected kits and aliquots of the specimens were sent to a DHHS certified lab for "gold standard" comparison testing by immunoassay and Gas Chromatography/Mass Spectrometry. On-site kit sensitivity ranged from 82.9% to 100% for THC, 82.5% to 100% for COC, and all were at 100% for OPI. Specificity, and positive and negative predictive values were also determined. Accuracy ranged from 94.0% to 98.3% for THC, 97.4% to 98.0% for COC, and 99.7% to 100% for OPI. All four kits were in very close agreement on prevalence: 15.5% to 15.8% for THC, all were at 13.2% for COC, and all were at 0.7% for OPI. For law enforcement purposes, sensitivity may be the most important indicator in these kits.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Development and application of a quantitative LC-MS/MS assay for the analysis of four dental local anesthetics in human plasma and breast milk.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Clinical Pharmacology Research Center, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China. Electronic address:
Local anesthetics (LAs: articaine, lidocaine, bupivacaine, and mepivacaine) are essential for dental pain management. However, there are concerns that the lipophilic LAs could cross into breast milk causing toxicity to the infant. Our objective was to establish a multi-analyte LC-MS/MS method for the concurrent quantification of local anesthetics (LAs) in human plasma and breast milk, clarifying the transfer of LAs from plasma to breast milk, thereby offering crucial data for the safe assessment of LAs during the nursing period.
View Article and Find Full Text PDFRegio selective deposition of conducting polymers using wireless electropolymerisation.
Chem Commun (Camb)
November 2024
School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
The ability to induce different potentials in different regions of a (bipolar) electrode could transform applications such as on-demand drug delivery, the electrostimulation of biological cells, the development of advanced electroceuticals, and multi-analyte detection devices where different analytes could be wirelessly detected in different regions of a single sensing surface dramatically simplifying the device design. Here, we demonstrate the use of multiple feeder electrodes to control the electric field distribution in solution thus changing the potential induced in different regions of the bipolar electrode depending on the feeder voltage, polarity and feeder electrode position. The principle is demonstrated for the deposition of films of the conducting polymer, Poly(3,4-EthyleneDiOxyThiophene) (PEDOT), without the need for a physical template to control the regions in which polymer deposits.
View Article and Find Full Text PDFAdipocyte maturation impacts daunorubicin disposition and metabolism.
Eur J Clin Invest
December 2024
Alfred Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA.
Introduction: Acute lymphoblastic leukaemia (ALL) is the most common type of childhood leukaemia with effective chemotherapeutic treatment. However, obesity has been associated with higher ALL chemoresistance rates and lower event-free survival rates. The molecular mechanism of how obesity promotes chemotherapy resistance is not well delineated.
View Article and Find Full Text PDFA multi-analyte assay of opioids in API and drug products using HPLC and HRMS.
J Pharm Biomed Anal
September 2024
US Food and Drug Administration, Division of Pharmaceutical Analysis, 645 S. Newstead Avenue, Saint Louis, MO 63110, United States.
Surveillance testing is an essential component to ensuring safe, effective, and high-quality drug products are available in the commercially marketed US supply chain. Surveillance allows the agency to assess product quality and monitor for potential adulteration of drug products being used by consumers. Opioid drug products can be adulterated to enhance the effect of the intended active ingredient.
View Article and Find Full Text PDFCharacterization of ribostamycin and its impurities using a nano-quantity analyte detector: Systematic comparison of performance among three different aerosol detectors.
Talanta
September 2024
Jiangsu Institute for Food and Drug Control, Nanjing, 210019, China; NMPA Key Laboratory for Impurity Profile of Chemical Drugs, Nanjing, 210019, China. Electronic address:
Article Synopsis
- * A novel aerosol detector called nano-quantity analyte detector (NQAD) was developed, offering higher sensitivity and a wider linear detection range compared to traditional detectors like ELSD and CAD.
- * The method also included using less toxic ion-pairs in the eluent and involved characterizing the impurities present in ribostamycin through liquid chromatography-mass spectrometry (LC-MS), promising more accurate results for quality control.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!