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Management of alar webbing using a CAD-CAM splint: A case report.
J Prosthodont
January 2025
Pediatric Plastic Surgery and Laurence C. Wright Craniofacial Center, John R. Oishei Children's Hospital, Buffalo, New York, USA.
Alar webbing is a functional and aesthetic defect of the nasal structure noted in cleft lip and palate patients (CLP), which is thought to be due to a deficiency in nasal lining tissue. Surgical procedures have previously focused on the removal of lining or alar cartilage leading to worse post-operative defects. This case demonstrates a novel technique of releasing the tissue, followed by using a CAD-CAM splint to help mold the tissue during the healing process to better control esthetics, symmetry, and prevent relapse.
View Article and Find Full Text PDFComparing Efficacy of Steroid Irrigation + Steroid-eluting Sinus Stent Versus Steroid Irrigation Alone for Maintaining Frontal Sinus Patency After Sinus Surgery: A Randomized Controlled Trial.
Int Forum Allergy Rhinol
January 2025
Department of Otolaryngology, Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Background: Steroid rinses and steroid-eluting stents are both options for preventing postoperative stenosis after frontal sinus surgery. This study aimed to assess whether steroid-eluting stents offer added benefit over steroid rinses alone in postoperative healing and long-term frontal sinus patency.
Methods: A randomized controlled trial enrolled patients with CRS with nasal polyps (CRSwNP) who underwent surgery for bilateral and equal frontal sinusitis after failing prior medical therapy.
A review of Secondary Intention Healing in Dermatology and Dermatologic Surgery: Part 1.
Clin Exp Dermatol
January 2025
Department of Dermatology, St Michaels Clinic, Shrewsbury, UK.
Secondary intention healing (SIH) describes wounds healing from the base upwards, without direct closure. This starts with granulation of the wound, followed by re-epithelialisation and contraction. The surgeon and patient need to weigh up advantages and disadvantages of SIH versus other reconstruction methods.
View Article and Find Full Text PDFBackground: Nasal defects after skin cancer excision can often be healed by second intention in certain circumstances.
Objective: We aim to demonstrate the utility of bovine collagen xenografts in supplementing second-intention healing of a variety of nose surgical defects.
Results: Thirty-nine patients underwent Mohs micrographic surgery of the nasal tip (33%), ala (23%), dorsum (31%), sidewall (10%), and root (3%) with the application of bovine collagen xenograft.
RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Article Synopsis
- RSPO3 is a specific protein that amplifies the WNT signaling pathway and plays a role in maintaining the function of adult stem cells, particularly limbal epithelial stem cells (LESCs) at the limbus.
- The study found that only RSPO3 is consistently expressed in the human limbus, where it enhances the proliferation and self-renewal of LESCs in a dose-dependent manner, independent of the traditional WNT/β-catenin signaling pathway.
- These findings suggest that RSPO3 could be a potential therapeutic target for improving wound healing in corneal injuries and addressing limbal stem cell deficiencies.
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