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Targeting Fibroblast-Derived Interleukin 6: A Strategy to Overcome Epithelial-Mesenchymal Transition and Radioresistance in Head and Neck Cancer.
Cancers (Basel)
January 2025
Head and Neck Oncology Group, Centre for Host Microbiome Interaction, King's College London, Hodgkin Building, London SE1 1UL, UK.
Background: Cancer-associated fibroblasts have been reported to play a central role in driving cancer progression, promoting metastasis, and conferring resistance to therapy in HNSCC.
Methods: Indirect and direct co-culture models of HPV-positive and HPV-negative HNSCC cells with fibroblasts were developed to study the effect of fibroblasts on cancer cells. ELISA was used to measure IL-6 secretion in these models.
Newborn with Refractory Seizures due to Hemimegalencephaly and Tuberous Sclerosis Complex: Case Report and Literature Review.
Neuropediatrics
January 2025
Division of Neonatology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
Hemimegalencephaly (HME) is a rare congenital disorder that is initiated during embryonic development with abnormal growth of one hemisphere. Tuberous sclerosis complex (TSC), a genetic disorder, is rarely associated with HME.We present a case of a newborn with HME with a confirmed mutation in the gene and describe the clinical course, findings on amplitude-integrated electroencephalography (aEEG), cranial ultrasound (CUS), MRI, and the postmortem evaluation.
View Article and Find Full Text PDFSingle-cell multi-omics analysis identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma.
Res Sq
December 2024
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, exhibiting clinical and genomic heterogeneity. Of the four major subgroups, Group 3 tumors (MYC-MB), display high levels of MYC and metastasis rates. Despite treatment with surgery, radiation, and chemotherapy, patients with Group 3 MB are more likely to develop aggressive recurrent tumors with poor survival.
View Article and Find Full Text PDFGastric Outlet Obstruction as a First Symptom of a Non-Muscle Invasive Bladder Cancer (NMIBC) Progression-A Case Report.
Cancer Rep (Hoboken)
December 2024
Department of Internal Medicine, Hospital St. Josef Braunau, Braunau am Inn, Austria.
Article Synopsis
- A 78-year-old male patient presented with persistent vomiting due to a rare case of metastatic urinary bladder cancer, which led to gastric outlet obstruction.
- Despite recent follow-up showing no disease recurrence, tests revealed duodenal stenosis and abnormal mesenteric fat swelling, initially misinterpreted as inflammation.
- A laparoscopic exploration confirmed peritoneal carcinomatosis, ultimately identifying urothelial cancer cells, highlighting the need for clinicians to think about metastatic bladder cancer in similar situations.
[Transarterial periarticular embolization (TAPE) for treatment of achillodynia: initial results].
Orthopadie (Heidelb)
December 2024
Klinik für Diagnostische und Interventionelle Radiologie, Helios Klinikum Krefeld, Lutherplatz 40, 47805, Krefeld, Deutschland.
Background: In recent years, transarterial periarticular embolization (TAPE) has received increasing attention in the treatment of chronic joint pain, which can be caused by degenerative changes such as osteoarthritis but also by inflammatory changes in the capsule-ligament apparatus.
Objectives: The aim of this study is to describe the method as well as preliminary results of TAPE in the treatment of therapy-resistant achillodynia.
Material And Methods: TAPE was used in the treatment of seven patients (female: 1, male: 6) with chronic achillodynia.
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