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Neuromyelitis Optica Spectrum Disorder With Unilateral Retrobulbar Neuritis: A Case Report.
Cureus
December 2024
Neurology and Neuroscience, Medical University of Varna, Varna, BGR.
Neuromyelitis optica spectrum disorder (NMOSD) includes conditions with autoimmune genesis, which are manifested by attacks of optic neuritis (ON) and transverse myelitis (TM), and also express aquaporin 4 (NMO-IgG) or myelin oligo-endocytic glycoprotein (MOGAb) antibodies. In rare cases, the disease may also have a clinical presentation with only TM, without ON or with ON, without TM. These conditions are also included in the spectrum.
View Article and Find Full Text PDFSevere Transverse Myelitis Following Ankle Surgery Potentially Unmasking Late-Onset Systemic Lupus Erythematosus.
Cureus
November 2024
Internal Medicine, ECU Health, Greenville, USA.
A 70-year-old female underwent open reduction and internal fixation (ORIF) of her right ankle following a mechanical trip and fell two weeks before hospital admission. Two weeks following surgery, the patient experienced sudden-onset bilateral anterior thigh paresthesias and burning mid-back pain. Over the ensuing two days, the patient developed bilateral lower extremity weakness, bilateral lower extremity numbness, and urinary retention with constipation, which led to hospital presentation.
View Article and Find Full Text PDFAutonomic disorder in systemic lupus erythematosus: autoimmune autonomic ganglionopathy.
Immunol Med
December 2024
Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University School of Medicine, Nishinomiya, Japan.
The pathomechanisms of autonomic disorders in systemic lupus erythematosus (SLE) remain unclear. We herein report a patient with SLE who developed autonomic disorders presumably caused by autoimmune autonomic ganglionopathy (AAG). A 42-year-old woman with SLE under treatment with corticosteroids and hydroxychloroquine was admitted for recurrence of SLE with thrombocytopenia and nephritis.
View Article and Find Full Text PDF"Lupus Myelitis" Revisited: A Retrospective Single-Center Study of Myelitis Associated With Rheumatologic Disease.
Neurol Neuroimmunol Neuroinflamm
January 2025
From the Division of Neuroimmunology and Neurological Infections (J.D.K., A.G.F., P.B., C.A.P., E.S.S.), Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD; Multiple Sclerosis and Neuroimmunology Center (P.B.), Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, University of California, Los Angeles; and Division of Rheumatology (A.C.G.), Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Background And Objectives: Previous reports of patients with myelitis associated with rheumatologic disease may have had unrecognized aquaporin-4 (AQP4)-IgG seropositive neuromyelitis optica spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein (MOG)-IgG-associated disease (MOGAD). We clinicoradiologically and serologically characterized patients with myelitis associated with rheumatologic disease evaluated in the era of availability of MOG-IgG and more sensitive AQP4-IgG cell-based assays.
Methods: A retrospective cohort (2018-2023) at Johns Hopkins Medicine with diagnoses of myelopathy and rheumatologic comorbidity was identified by electronic medical record (EMR) query.
Central Nervous System Imaging in Rheumatic Diseases.
Rheum Dis Clin North Am
November 2024
Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Lerner College of Medicine, Center for Vasculitis Care & Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:
Article Synopsis
- Rheumatic diseases can lead to various central nervous system (CNS) issues, including strokes, seizures, and headaches, along with demyelinating conditions like optic neuritis.* -
- CNS problems often occur alongside other systemic symptoms of the rheumatic disease, but in some cases, neurological symptoms may be the first indication of the disease.* -
- The review focuses on different rheumatic diseases that affect the CNS and highlights neuroimaging findings in affected patients.*
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