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The effect of conditioned medium from human amniotic membrane-derived mesenchymal stem cells on thymus involution.
Life Sci
January 2025
3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho; Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine; Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory; Braga/Guimarães, Portugal. Electronic address:
Aims: The development and selection of T cells occur within the thymus. This organ involutes throughout life, compromising the generation of T cells and, consequently, the efficacy of the immune system. Mesenchymal stem cells (MSC) have beneficial effects on the immune system.
View Article and Find Full Text PDFTurcz. Root Bark Improves Skin Barrier Function and Symptoms of Atopic Dermatitis in Mice.
Int J Mol Sci
December 2024
Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
The root bark of Turcz. has been traditionally used for the topical treatment of skin disorders like pruritus. This study was designed to investigate the inflammatory and skin barrier protective effects of in mice with calcipotriol (MC903)-induced atopic dermatitis (AD).
View Article and Find Full Text PDFEmerging Anti-Inflammatory COPD Treatments: Potential Cardiovascular Impacts.
Int J Chron Obstruct Pulmon Dis
November 2024
Unit of Pharmacology, Department of Experimental Medicine, University of Campania 'luigi Vanvitelli', Naples, Italy.
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition often complicated by cardiovascular disease (CVD) due to shared inflammatory pathways. This review explores the cardiovascular impacts of emerging anti-inflammatory therapies in COPD. Phosphodiesterase (PDE) inhibitors may offer anti-inflammatory effects with improved lung function but pose potential risks for arrhythmias when PDE3 is inhibited although PDE4 inhibitors reduce cardiovascular events by improving endothelial function and reducing thrombosis.
View Article and Find Full Text PDFThymic epithelial cell responses to the friedelin triterpene .
Nat Prod Res
November 2024
Laboratory of Cell Biology, Institute of Biological and Health Sciences, Federal University of Alagoas, Maceió, Brazil.
Thymic epithelial cells (TECs) dysfunction can lead to disorders in the adaptive immune response, resulting in immunodeficiency or autoimmune diseases. Therefore, the investigation of new drugs with immunomodulatory capacity can contribute to the development of strategies to improve thymic functions. In this context, this study aimed to investigate the effects of the pentacyclic triterpene friedelin (FD) on TEC biology.
View Article and Find Full Text PDFFood for thought: Nutrient metabolism controlling early T cell development.
Bioessays
January 2025
Department of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
T cells develop in the thymus by expressing a diverse repertoire of either αβ- or γδ-T cell receptors (TCR). While many studies have elucidated how TCR signaling and gene expression control T cell ontogeny, the role of nutrient metabolism is just emerging. Here, we discuss how metabolic reprogramming and nutrient availability impact the fate of developing thymic T cells.
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