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Increased FGF-19 levels following explantation in women with breast implant illness.
Sci Rep
January 2025
Section General Internal Medicine, Department of Internal Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Breast Implant Illness (BII) is characterized by a cluster of systemic and local symptoms affecting a subset of women with silicone breast implants. While symptom improvement is frequently observed following implant removal, the underlying mechanisms remain poorly understood, and the absence of reliable biomarkers complicates clinical decision-making. Here, we investigate inflammatory protein profiles in 43 women with BII, comparing pre- and post-explantation levels using the Olink Target 96 Inflammation panel and Meso Scale Discovery technology for absolute quantification.
View Article and Find Full Text PDFMulticentre, double-blind, randomised controlled clinical trial comparing intermittent cefoxitin administration versus loading bolus followed by continuous infusion for the prevention of surgical site infection in colorectal surgery: the PROPHYLOXITIN study protocol.
BMJ Open
January 2025
Université de Poitiers, INSERM U1070 PHAR2, CHU de Poitiers, Service d'Anesthésie-Réanimation et Médecine Péri-Opératoire, Poitiers, France
Introduction: Surgical site infections (SSIs) are the second leading cause of healthcare-associated infections in Europe with the highest rates being reported in colorectal surgery (ranging from 9% to 30%). Surgical antibiotic prophylaxis (SAP) is one of the most efficient measures for SSI prevention and should be started before surgical incision. Cefoxitin is an antibiotic widely used as SAP for colorectal surgery, but its continuous administration is currently the subject of debate due to its potential pharmacokinetic advantages.
View Article and Find Full Text PDFActivation of G protein gated inwardly rectifying potassium (GIRK) channels in keratinocytes mediates peripheral kappa opioid receptor-mediated antinociception.
Neuropharmacology
January 2025
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, USA. Electronic address:
Kappa opioid receptors (KOR) expressed by peripheral pain-sensing neurons (nociceptors) are a promising target for development of effective and safer analgesics for inflammatory pain that are devoid of central nervous system adverse effects. Here we sought to delineate the signaling pathways that underlie peripheral KOR-mediated antinociception in adult male and female Sprague-Dawley rats. In an inflammatory model of pain, local intraplantar (i.
View Article and Find Full Text PDFTHE IMPACT OF NEUTROPHIL-TO-LYMPHOCYTE RATIO ON SHORT- AND LONG-TERM PROGNOSIS FOLLOWING ELECTIVE INFRARENAL EVAR.
Ann Vasc Surg
January 2025
Hospital de Santa Marta, Unidade Local de Saúde São José, Lisboa, Portugal.
Objective: Neutrophil-to-lymphocyte ratio (NLR) is a readily available parameter, associated with long-term outcomes in cardiovascular conditions. This study aims to analyze the predictors of NLR and its impact on prognosis and disease-specific outcomes following EVAR.
Methods: Single-center retrospective cohort study.
Assessing the potential acoustic impact of floating offshore wind farms in the Central Mediterranean Sea.
Mar Pollut Bull
January 2025
Institute for the study of anthropogenic impacts and sustainability in the marine environment, National Research Council of Italy, Via del Mare 3, 91021 Torretta Granitola, Italy.
The Strait of Sicily, a vital marine passage with diverse fauna, is seeing a steep rise in the planning of offshore wind farm projects. This study assesses the acoustic impact of these wind farms on local marine species. Underwater propagation was modeled for three proposed floating wind farms using JASCO's Marine Operations Noise Model (MONM), which integrates a parabolic equation method for frequencies from 10 to 800 Hz and a beam-tracing model for 1 to 25 kHz.
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