AI Article Synopsis
- The study aimed to evaluate how heart-rate variability (HRV) over 24 hours correlates with the effectiveness of fluoxetine and doxepin treatments for depression.
- Ten out of 14 patients showed a positive response to the treatment, with noticeable increases in specific HRV measures like SDANN associated with their recovery.
- The findings suggest that monitoring 24-hour HRV could be a helpful tool in assessing how well patients respond to antidepressant therapy, but no significant differences were found between the two medications.
Article Abstract
Objective: To assess the 24-hour temporal-domain heart-rate variability correlates of treatment with fluoxetine or doxepin for depression.
Method: A randomized evaluation of fluoxetine and doxepin measured a 50% change in the Hamilton Depression Rating Scale (HDRS) score as a response to therapy and was correlated with measures of standard deviation of the mean of all 5-minute segments of normal electrocardiographic R-R intervals (SDANN), standard deviation of all normal R-R intervals (SDNN), root mean square of successive differences in R-R intervals (r-MSSD), and percentage difference between adjacent normal R-R intervals that are greater than 50 msec (pNN50) from 24-hour electrocardiogram (ECG) tapes.
Results: Ten out of 14 patients responded. Response was associated with an increase in SDANN of 17% (P < 0.05). Nonresponse was associated with a 17% decrease in SDANN and a 22% decrease in SDNN (both P < 0.05). No other measures correlated with therapeutic response. No heart-rate variability (HRV) differences between the 2 drug therapies were observed.
Conclusion: Twenty-four-hour HRV measures may be useful in assessing response to antidepressant therapy.
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| http://dx.doi.org/10.1177/070674379804300209 | DOI Listing |
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