AI Article Synopsis
- Coenzyme Q10 was tested in a placebo-controlled study involving six subjects with type 3 3-methylglutaconic aciduria, inspired by previous reports suggesting potential benefits.
- Despite achieving high levels of coenzyme Q10 in the blood, no noticeable clinical improvements were observed in the subjects.
- Additionally, there was no reduction in the urinary output of 3-methylglutaconic acid, indicating that the treatment was ineffective.
Article Abstract
Coenzyme Q10 was administered under placebo controlled blinded crossover conditions to six subjects suffering from type 3 3-methylglutaconic aciduria ('optic atrophy plus'), following a report of benefit. Despite attainment of high plasma levels of coenzyme Q10, no clinical benefit was observed and there was no diminution of urinary excretion of 3-methylglutaconic acid.
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| http://dx.doi.org/10.1016/s0387-7604(97)00096-x | DOI Listing |
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