The work on the evaluation of the role of rubella infection in the development of congenital malformations in newborn infants, as well as the immunogenic activity and tolerability of live attenuated vaccine Rudivax (Pasteur Mérieux Connaught) was carried out in the process of selective immunization in the Perm region. The study made it possible to find out 15% of malformations in the structure of the congenital pathology of newborn infants, which appeared due to the infection of the fetus with rubella virus and were manifested by multiple development defects, congenital C.N.S. defects and valvular defects. The results of using vaccine Rudivax in the epidemiological trial demonstrated that the vaccine had high immunological activity and was well tolerated. The absence of postvaccinal complications after the injection of the live vaccine and the absence of the extinction of immunity in the presence antibodies were indicative of the possibility vaccination without preliminary serological examination.
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