Vibrio cholerae eltor has been shown to exist in two variants: epidemic (V. cholerae eltor Hly-, tox+) and nonepidemic, or endemic (V. cholerae eltor Hly+, tox-); each of these variants determines the corresponding form of manifestation of the infection among the population and requires a differentiated complex of antiepidemic measures, as well as different tactics for the treatment of patients.

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Vibrio cholerae, the causative agent of cholera, is commonly isolated, along with other bacterial species, from chironomid insects (Diptera: Chironomidae). Nevertheless, its prevalence in the chironomid egg masses' microbiota is less than 0.5%.

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Computational image analysis of the baseplate-tail complex of O1 ElTor vibriophage M4.

Arch Virol

November 2020

Division of Electron Microscopy, ICMR-National Institute of Cholera and Enteric Diseases, P-33 C.I.T Road, Scheme-XM, Beleghata, Kolkata, 700010, India.

We performed an in-depth computational image analysis of the baseplate-tail complex of the M4 vibriophage and identified seven major densities in its baseplate, which notably share structural similarities with baseplate modules of a number of other bacteriophages belonging to different species. Employing computational analysis, we explained the helical organization of the sheath protein, wrapping the tail tube. Based on the results obtained in this work along with the proteomics information published previously, we are able to decipher the plausible roles assigned to the different components of the M4 baseplate during infection of the host.

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Background: Cholera is a primordial disease caused by which existed from centuries in different parts of the world and still shows its periodic, endemic and epidemic presence. Thousands of cholera cases are reported from different parts of India and the disease remains endemic throughout the year. At present, we do not have enough knowledge about the phenotypic nature of the circulating strains in this part of the world.

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Seasonal Pattern of Pathogenic V. cholerae and V. paraheamolyticus in Surface Water of Dhaka, Bangladesh.

Mymensingh Med J

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Azizul Kabir, MS student, Department of Microbiology, University of Dhaka, Dhaka, Bangladesh.

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