AI Article Synopsis
- The study tested a new buccal dosage form of aspirin called ascolong, which has a low dose of 12.5 mg of acetylsalicylic acid (ASA), focusing on its safety and effectiveness.
- The research involved 43 healthy men for drug tolerance and 19 patients with heart or vascular issues, comparing the effects of ascolong with placebo and traditional aspirin.
- Results showed ascolong provided a reliable antiaggregant effect, albeit weaker than regular aspirin, and was well-tolerated, making it a potential option for those who cannot take oral aspirin.
Article Abstract
Aim: Study of the tolerance and pharmacodynamic and pharmacokinetic characteristics of ascolong, a new buccal dosage form of aspirin containing a very low dose of acetylsalicylic acid (ASA): 12.5 mg.
Materials And Methods: The study was carried out in 43 healthy men (assessment of the drug tolerance) and 19 male patients with coronary disease or cerebrovascular disorders. In 10 patients the antiaggregant efficacy of ascolong administered once or regularly (for 2 weeks) in a dose of 12.5 mg was compared with placebo, in 9 patients a random cross study of 2-week courses of ascolong and Russian aspirin tablets in a dose of 100 mg was carried out. Platelet aggregation was assessed on days 1 and 14 of each course before and 2, 4, and 24 h after the drug intake.
Results: Ascolong containing a very low dose of ASA exerts a reliable antiaggregant effect after a single and regular intake, although this effect is less manifest than after aspirin tablets. Profiles of ASA concentrations in the blood were studied. Transbuccal entry of ASA in systemic circulation decelerated its metabolism into a less active metabolite, salicylic acid, due to which fact the ASA microdose had an expressed antiaggregant effect. The drug was sufficiently well tolerated.
Conclusion: The new buccal film form of aspirin containing a very low dose of ASA possesses a good antiaggregant effect and is promising in subjects with contraindications to oral intake of aspirin.
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