[Efficacy of moxonidine, an imidazoline receptor agonist, in patients with essential hypertension].

Aim: Study of zint (moxonidine), a hypotensive drug with the central mechanism of action.

Materials And Methods: The hemodynamics and platelet functional activity were assessed in 30 patients with essential hypertension treated by zint in a daily dose of 0.4 mg, taken in the morning, for 3 months.

Results: By the end of treatment the systolic arterial pressure decreased by 23 +/- 4 mm Hg, diastolic by 15 +/- mm Hg, mean pressure by 17 +/- 2 mm Hg, and heart rate by 5 +/- 4 str/min. Echography showed that myocardial hypertrophy decreased but negligibly. An evident decrease of ADP-induced platelet aggregation was observed.

Conclusion: Zint therapy may be a most physiological method of arterial hypertension control.