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Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice.
Front Immunol
September 2023
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hepatic ischemia/reperfusion injury (IRI) often causes serious complications in liver surgeries, including transplantation. Complement activation seems to be involved in hepatic IRI; however, no complement-targeted intervention has been clinically applied. We investigated the therapeutic potential of Properdin-targeted complement regulation in hepatic IRI.
View Article and Find Full Text PDFIn vivo study on the healing of bone defect treated with non-thermal atmospheric pressure gas discharge plasma.
PLoS One
November 2021
Department of Orthopedic Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Medical treatment using non-thermal atmospheric pressure plasma (NTAPP) is rapidly gaining recognition. NTAPP is thought to be a new therapeutic method because it could generate highly reactive species in an ambient atmosphere which could be exposed to biological targets (e.g.
View Article and Find Full Text PDFTowards the translation of electroconductive organic materials for regeneration of neural tissues.
Acta Biomater
February 2022
Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville 32611, FL, United States. Electronic address:
Carbon-based conductive and electroactive materials (e.g., derivatives of graphene, fullerenes, polypyrrole, polythiophene, polyaniline) have been studied since the 1970s for use in a broad range of applications.
View Article and Find Full Text PDFThe complexities of PKCα signaling in cancer.
Adv Biol Regul
May 2021
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address:
Protein kinase C α (PKCα) is a ubiquitously expressed member of the PKC family of serine/threonine kinases with diverse functions in normal and neoplastic cells. Early studies identified anti-proliferative and differentiation-inducing functions for PKCα in some normal tissues (e.g.
View Article and Find Full Text PDFThermo-Responsive Methylcellulose Hydrogels: From Design to Applications as Smart Biomaterials.
Tissue Eng Part B Rev
October 2021
Department of Chemistry, Materials and Chemical Engineering "G. Natta," Politecnico di Milano, Milan, Italy.
Methylcellulose (MC) is an attractive material used to produce thermo-responsive hydrogels. They undergo sol-gel transition when a critical temperature is reached, thus modifying their properties (e.g.
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