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Single-fraction high-dose-rate brachytherapy as monotherapy for localized prostate cancer: long-term follow-up study based on meta-analysis.
J Cancer
January 2025
Department of Radiation Oncology, Nanyang Central Hospital, Nanyang, Henan, 473005, China.
Article Synopsis
- Single-fraction high-dose-rate brachytherapy (SFHDR-BT) for localized prostate cancer has yet to be fully supported by medical evidence, necessitating a thorough evaluation of its long-term safety and effectiveness.
- A review of multiple studies revealed that SFHDR-BT is generally well tolerated, with low rates of severe gastrointestinal (0%) and genitourinary toxic effects (3%), but with a notable occurrence of grade ≥ 3 sexual dysfunction (4%).
- Long-term outcomes showed a biological recurrence-free survival (bRFS) rate of 72% and an overall survival (OS) rate of 90%, indicating that while tolerable, the clinical benefits of SFHDR-BT may be suboptimal, highlighting the need for high
Targeted microwave ablation of localised prostate cancer: Initial results of VIOLETTE trial.
BJUI Compass
December 2024
Department of Urology, Jules Bordet Institute, Hôpital Universitaire de Bruxelles Université Libre de Bruxelles Brussels Belgium.
Objective: The aim of this study was to assess the precision and safety of targeted microwave ablation (TMA) using organ-based tracking (OBT) fusion, in patients with intermediate risk prostate cancer.
Patients And Method: We conducted a prospective, multicentric trial. Eligible patients had a prostate-specific antigen (PSA) < 20 ng/mL, a magnetic resonance imaging (MRI)-visible index tumour of Gleason score 3 + 4, with largest axis ≤15 mm and distant of at least 5 mm from the rectum and apex.
Mercuric chloride induced reproductive toxicity associated with oxidative damage in male Wistar albino rat, Rattus norvegicus.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Zoology, Karnataka University, Dharwad, Karnataka, 580003, India.
In the field of toxicology, male reproductive hazards attributed to metal exposure is a fast-developing issue. Mercury has been identified as an environmental pollutant that causes potential adverse impacts on organisms. This study aimed to assess the reprotoxic consequences of mercuric chloride (HgCl).
View Article and Find Full Text PDFMagnitude and factors associated with benign prostatic hyperplasia among adult male patients visiting Wolaita Sodo University comprehensive specialized hospital southern Ethiopia.
Sci Rep
December 2024
Department of Biomedical Sciences, College of Medicine and Health Sciences, Wachemo University, Hossana, Ethiopia.
Worldwide, in Africa and Ethiopia prevalence of Benign Prostatic Hyperplasia among patients with lower urinary tract symptoms was 26.2%, 44.2%, and 33.
View Article and Find Full Text PDFEffect of repeated semen ejaculation on sperm quality and selected biochemical markers of canine semen.
Pol J Vet Sci
June 2024
Department of Animal Biochemistry and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-718 Olsztyn-Kortowo, Poland.
The aim of this study was to evaluate the quality parameters and selected biochemical markers of canine semen sampled at 24-h intervals over a period of 5 days, preceded by 6 months of sexual abstinence. Full ejaculates were obtained from 6 dogs. Ejaculate volume and total sperm counts in the ejaculate decreased gradually on successive sampling days.
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