We encountered an unusual case of pemphigus foliaceus in which there were early clinical signs of dermatitis herpetiformis with eosinophilic spongiosis histologically. Numerous authors have appreciated that eosinophilic spongiosis occurs in early pemphigus foliaceus, usually in the preacantholytic stage when the lesions may clinically simulate dermatitis herpetiformis. Recognition of eosinophilic spongiosis may help differentiate early pemphigus from other vesiculobullous disorders.
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Department of Dermatology, University of California Davis School of Medicine, Sacramento, California; Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, California. Electronic address:
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Article Synopsis
- Atopic dermatitis (AD) is a skin condition that makes the skin itchy, irritated, and not able to protect itself properly.
- It often starts in childhood and can lead to other allergies and asthma as a person grows up, in something called the "atopic march."
- Scientists use different models to study AD and find new treatments, but it's tough to create a model that shows all the real-life symptoms of the condition.
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