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Towards the Stable Chelation of Radioantimony(V) for Targeted Auger Theranostics.
Angew Chem Int Ed Engl
January 2025
Oak Ridge National Laboratory, Chemical Sciences Division, UNITED STATES OF AMERICA.
Antimony-119 (119Sb) is one of the most attractive Auger-electron emitters identified to date, but it remains practically unexplored for targeted radiotherapy because no chelators have been identified to stably bind this metalloid in vivo. In a departure from current studies focused on chelator development for Sb(III), we explore the chelation chemistry of Sb(V) using the tris-catecholate ligand TREN-CAM. Through a combination of radiolabeling, spectroscopic, solid-state, and computational studies, the radiochemistry and structural chemistry of TREN-CAM with 1XX/natSb(V) were established.
View Article and Find Full Text PDFThe 'inflammazone' in chronic inflammatory diseases: psoriasis and sarcoidosis.
Trends Immunol
January 2025
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; Nanhai Clinical Translational Center, Sun Yat-sen Memorial Hospital, Foshan, China; Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Zenith Institute of Medical Sciences, Guangzhou 510120, China. Electronic address:
Chronic inflammatory diseases show significant heterogeneity in their phenotypes, with diverse immune cells and mediators interacting in response to various stimuli. This review proposes the concept of the 'inflammazone' framework - which maps the distribution of immune components driving disease pathogenesis - using sarcoidosis and psoriasis as examples. Sarcoidosis features granulomatous inflammation with macrophages and CD4 T cells, which can spread to lymph nodes and other organs.
View Article and Find Full Text PDFEvaluating dental students' satisfaction in clinical Periodontics courses at KSAU-HS: a cross-sectional study.
BMC Med Educ
January 2025
Preventive Dental Science Department, College of Dentistry, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Background: The National Commission for Academic Accreditation and Assessment (NCAAA) in Saudi Arabia underscores the importance of assessing student satisfaction to ensure program quality. No previous studies have explored the satisfaction levels of dental students enrolled in clinical Periodontics courses at King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS). This study aims to assess dental students' satisfaction with clinical Periodontics courses and to explore potential differences in satisfaction based on gender and academic level.
View Article and Find Full Text PDFValidity of one-time phantomless patient-specific quality assurance in proton therapy with regard to the reproducibility of beam delivery.
Med Phys
January 2025
OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.
Background: Patient-specific quality assurance (PSQA) is a crucial yet resource-intensive task in proton therapy, requiring special equipment, expertise and additional beam time. Machine delivery log files contain information about energy, position and monitor units (MU) of all delivered spots, allowing a reconstruction of the applied dose. This raises the prospect of phantomless, log file-based QA (LFQA) as an automated replacement of current phantom-based solutions, provided that such an approach guarantees a comparable level of safety.
View Article and Find Full Text PDFSpatiotemporal dynamics and driving factors of energy-related carbon emissions in the Yangtze River Delta region based on nighttime light data.
Sci Rep
January 2025
School of Surveying and Land Information Engineering, Henan Polytechnic University, Jiaozuo, 454003, China.
Owing to China's massive area and vastly differing regional variations in the types and efficiency of energy, the spatiotemporal distributions of regional carbon emissions (CE) vary widely. Regional CE study is becoming more crucial for determining the future course of sustainable development worldwide. In this work, two types of nighttime light data were integrated to expand the study's temporal coverage.
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