1. In this study, the effects of lead acetate on two types of pain (nociception and inflammation) induced by formalin and its interactions with opioid system and morphine-induced analgesia were examined. Male albino mice weighing 22-27 g were used in the experiments. 2. To study nociception, the formalin test was selected. Morphine was administered subcutaneously 30 min before formalin injection. Lead acetate treatment was administered 90 min before any injection. Comparisons between groups were made by analysis of variance and then by Newman-Keuls test. Differences with P < or = 0.05 was considered statistically significant. 3. Different doses of morphine induced antinociception in both phases of the formalin test. Lead acetate induced non-dose-dependent nociception in the early phase and dose-dependent analgesia in the late phase. 4. Pretreatment with lead acetate antagonized the effect of morphine in the early phase. In the other hand, the effect of lead acetate in the early phase was reduced by morphine and its effect eliminated in the late phase. 5. It is concluded that lead can modulate pain response and interact with morphine-induced antinociception. Additional research to find the mechanisms of these effects are suggested.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0306-3623(97)00283-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Imaging pathology in archived cornea with Fuchs' endothelial corneal dystrophy including tissue reprocessing for volume electron microscopy.
Sci Rep
December 2024
Structural Biophysics Research Group, School of Optometry & Vision Sciences, Cardiff University, Cardiff, Wales, UK.
Fuchs' endothelial corneal dystrophy (FECD) is a common sight-threatening condition characterised by pathological changes in the posterior cornea. Here we report observations by light, transmission and volume scanning electron microscopy on changes in the endothelium and matrix associated with the characteristic deformations of Descemet's membrane, termed guttae. Specimens were archived full-thickness human corneal tissue, removed during graft surgery, that had been fixed, stained and embedded by conventional processing methods for examination by transmission electron microscopy more than 40-years previously.
View Article and Find Full Text PDFGrowth, structural adaptations, and physiological dynamics of Colla. toward lead toxicity.
Int J Phytoremediation
December 2024
Department of Botany, Sree Neelakanta Government Sanskrit College, Pattambi, India.
Anthropogenic activities have accelerated lead (Pb) accumulation across different trophic levels in the ecosystem. This study focused on the physiological mechanisms of an invasive plant, in a controlled hydroponic setting to understand its response to Pb stress. was exposed to 680 µM of lead acetate for 21 days, showing high tolerance (83%) with minimal growth inhibition.
View Article and Find Full Text PDFThe Effectiveness of Levamisole and Broccoli in Lead Poisoning: Hematobiochemical Changes and Tissue Damage in the Liver, Kidney, and Spleen of Wistar Rats.
J Toxicol
November 2024
Department of Pathobiology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
Lead, a heavy metal, has emerged as one of the most significant pollutants, bearing irreversible consequences on human and animal health in conjunction with industrial development. Presently, the use of medicinal plants to alleviate the adverse effects of heavy metal toxicity has captured the attention of researchers. Hence, the objective of this study was to assess the impact of levamisole and broccoli extract on the electrophoretic pattern of serum proteins, hematological parameters, and histopathological alterations in the liver, kidney, and spleen tissues within a lead poisoning model of rats.
View Article and Find Full Text PDFDietary Nannochloropsis oculata ameliorates lead acetate induced reproductive toxicity in Barki rams: NF-κB and cytokines pathways.
Ecotoxicol Environ Saf
December 2024
Department of Theriogenology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
Article Synopsis
- The study investigated how the algae Nannochloropsis oculata (N. oculata) can protect rams from reproductive damage caused by lead toxicity.
- Sixteen Barki rams were divided into four groups: one control group, one group fed with N. oculata, one group exposed to lead acetate, and one group receiving both N. oculata and lead.
- Results showed that N. oculata improved semen quality, testosterone levels, and antioxidant status while reducing inflammation, indicating it can counteract the harmful effects of lead on reproduction in rams.
Protective Role of Vitamin B6 Against Teratogenic Effects Induced by Lead in Chick Embryo.
Birth Defects Res
December 2024
Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan.
Article Synopsis
- Lead exposure has increased since the industrial revolution, posing serious health risks as it serves no purpose in the human body and is still used in various industries, like battery manufacturing.* -
- This study examined the harmful effects of lead on chick embryos, noting significant growth reductions and deformities, while also assessing the potential of vitamin B6 to counteract these effects.* -
- Results showed that vitamin B6 improved embryo weight and reduced lead's negative impacts, indicating it may help protect against lead toxicity during development.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!