The purpose of the study was to identify psychosocial predictors of interest in prenatal genetic testing. Analysis of data from 886 responses in the 1996 Louisville Metropolitan Survey indicate that factors such as demographic characteristics and scores on health locus of control that predict utilization of other preventive health care are less applicable to predicting attitudes toward genetic testing. Regression analyses indicated that political orientation, identification with religion, and attitudes against abortion predicted less favorable responses to a question about prenatal genetic testing. Abortion attitudes were particularly strong indicators of respondents' stated interests in testing. The findings have practical implications in terms of promoting preventive health care. Personal values may lead individuals to believe that prenatal testing leads to the intention of abortion.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.2466/pr0.1998.82.1.235 | DOI Listing |
Adv Sci (Weinh)
December 2024
Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Despite the well-documented mutation spectra of β-thalassemia, the genetic variants and haplotypes of globin gene clusters modulating its clinical heterogeneity remain incompletely illustrated. Here, a targeted long-read sequencing (T-LRS) is demonstrated to capture 20 genes/loci in 1,020 β-thalassemia patients. This panel permits not only identification of thalassemia mutations at 100% of sensitivity and specificity, but also detection of rare structural variants (SVs) and single nucleotide variants (SNVs) in modifier genes/loci.
View Article and Find Full Text PDFPol J Vet Sci
December 2024
Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, Warszawska 30, 10-082 Olsztyn, Poland.
This is the first study aimed to investigate the innervation of the internal genital organs in 12-week-old female pig foetuses using single and double-labelling immunofluorescence methods. Immunostaining for protein gene product 9.5 (PGP, general neural marker) revealed that the most numerous PGP-positive nerve fibres were found in the mesenchyme of the uterovaginal canal height.
View Article and Find Full Text PDFFront Nutr
December 2024
Department of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.
Background/objectives: Schizophrenia is a complex mental disorder influenced by genetic and environmental factors, including dietary habits. Oxidative stress and inflammation play a crucial role in the pathophysiology of schizophrenia. Emerging research suggests that diet may affect schizophrenia through different biological mechanisms beyond oxidative stress and inflammation.
View Article and Find Full Text PDFSci Rep
December 2024
College of Physical Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Nanomaterial-biomembrane interactions constitute a critical biological process in assessing the toxicity of such materials in theoretical studies. However, many investigations simplify these interactions by using membrane models containing only one or a few lipid types, deviating significantly from the complexity of real membrane compositions. In particular, cholesterol, a ubiquitous lipid essential for regulating membrane fluidity and closely linked to various diseases, is often overlooked.
View Article and Find Full Text PDFGene
December 2024
Department of Medical Genetics/Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510515, China; Department of Fetal Medicine and Prenatal Diagnosis, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China. Electronic address:
Background/aim: Autosomal-recessive carnitine-acylcarnitine translocase deficiency (CACTD) is a rare disorder of long-chain fatty acid oxidation caused by variants in the SLC25A20 gene. Under fasting conditions, most newborns with severe CACTD experience sudden cardiac arrest and hypotonia, often leading to premature death due to rapid disease progression. Understanding of genetic factors and pathogenic mechanisms in CACTD is essential for its diagnosis, treatment, and prevention.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!