Objective: This study aimed to analyze the etiologies, clinical presentation, treatment options, and results of treatment in a series of patients with acquired external auditory canal atresia (AEACA) and to put this analysis in the context of the existing literature on this topic.
Study Design: The study design was a retrospective case review.
Setting: The study was performed at a tertiary otologic referral practice.
Patients: This study included patients with soft tissue AEACA.
Intervention: Patients received surgical excision of atresia process, conchomeatoplasty, canalplasty, and, when indicated, split-thickness skin graft (STSG) reconstruction.
Main Outcome Measures: These included definition of a characteristic patient profile and the incidence of postoperative complications including restenosis.
Results: This series of six patients is unusual in that in all patients, atresia resulted either from prior surgery or trauma rather than from chronic infection, which is the most commonly seen etiology in the literature. An average of 14 years' lag time transpired between the inciting event and the surgical repair. Five of six patients required STSG for reconstruction; all did well. The single patient who did not require STSG had a minor restenosis develop that did not require revision surgery.
Conclusions: Acquired external auditory canal atresia often is caused by trauma or prior surgery. Years may elapse between the inciting event and reconstructive surgery. The use of an STSG can be an important component to a successful surgical outcome.
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J Med Imaging (Bellingham)
January 2025
U.S. Food and Drug Administration, Office of Science and Engineering Labs, Division of Imaging, Diagnostics, and Software Reliability, Silver Spring, Maryland, United States.
Purpose: We evaluate the impact of charge summing correction on a cadmium telluride (CdTe)-based photon-counting detector in breast computed tomography (CT).
Approach: We employ a custom-built laboratory benchtop system using the X-THOR FX30 0.75-mm CdTe detector (Varex Imaging, Salt Lake City, Utah, United States) with a pixel pitch of 0.
Biochemistry (Mosc)
December 2024
Faculty of Biology, St. Petersburg State University, St. Petersburg, 199034, Russia. ARRAY(0x5ae2b7af6df8).
Amyloids are protein fibrils with a characteristic cross-β structure that is responsible for the unusual resistance of amyloids to various physical and chemical factors, as well as numerous pathogenic and functional consequences of amyloidogenesis. The greatest diversity of functional amyloids was identified in bacteria. The majority of bacterial amyloids are involved in virulence and pathogenesis either via facilitating formation of biofilms and adaptation of bacteria to colonization of a host organism or through direct regulation of toxicity.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2025
Key Laboratory of Optoelectronic Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China.
Antimonide laser diodes, with their high performance above room temperature, exhibit significant potential for widespread applications in the mid-infrared spectral region. However, the laser's performance significantly degrades as the emission wavelength increases, primarily due to severe quantum-well hole leakage and significant non-radiative recombination. In this paper, we put up an active region with a high valence band offset and excellent crystalline quality with high luminescence to improve the laser's performance.
View Article and Find Full Text PDFEur Respir J
January 2025
Center for Experimental and Molecular Medicine (CEMM), Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Introduction: Immune response dysregulation has been implicated in the development of intensive care unit (ICU)-acquired pneumonia. We aimed to determine differences in the longitudinal blood transcriptional response between patients who develop ICU-acquired pneumonia (cases) and those who do not (controls).
Methods: We performed a case-cohort study in mechanically ventilated trauma and surgery patients with ICU stays >2 days, enrolled in 30 hospitals across Europe.
Child Abuse Negl
January 2025
Department of Psychology, Institute of Special Environmental Medicine, Nantong University, 9 Seyuan Road, Nantong 226019, Jiangsu Province, China.
Objectives: In recent years, juvenile delinquency has continued to occur at a high rate, necessitating attention to its criminal psychological process and underlying risk factors.
Methods: This study acquired psychological review data from 97 juvenile delinquents in China. Utilizing qualitative analysis, we delved into the psychological processes and risk factors that contribute to juvenile delinquency, aiming to reveal the psychological mechanisms involved.
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