Continuous perfusion was applied in studying the absorption of essential amino acids in the duodenum and the proximal part of the jejunum in healthy persons and in patients with chronic enteritis of the land ii degrees of severity. All the patients demonstrated a reduced rate of absorption. The degree of the absorption derangement increased parallel with the severity of the affection. In the duodenum the absorption proceeded slower than in the upper portion of the jejunum.

Download full-text PDF

Source

Publication Analysis

Top Keywords

essential amino
8
amino acids
8
patients chronic
8
[absorption essential
4
acids patients
4
chronic enteritis]
4
enteritis] continuous
4
continuous perfusion
4
perfusion applied
4
applied studying
4

Similar Publications

L-carnitine protects against oxidative damage and neuroinflammation in cerebral cortex of rats submitted to chronic chemically-induced model of hyperphenylalaninemia.

Metab Brain Dis

January 2025

Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, Porto Alegre, CEP 90610-000, RS, Brazil.

Phenylketonuria is a genetic disorder characterized by high phenylalanine levels, the main toxic metabolite of the disease. Hyperphenylalaninemia can cause neurological impairment. In order to avoid this symptomatology, patients typically follow a phenylalanine-free diet supplemented with a synthetic formula that provides essential amino acids, including L-carnitine.

View Article and Find Full Text PDF

Background: This study examines the influence of prematurity and diabetes (DM) in pregnancy on metabolite patterns at birth, and associations with adiposity development in a prospective cohort.

Methods: Term and preterm (30-36 weeks gestational age [GA]) infants were enrolled and body composition assessments completed through discharge. Targeted metabolomics was used to assess metabolites in cord or infant blood in the first 2 days.

View Article and Find Full Text PDF

Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention.

Nat Metab

January 2025

Institute of Environmental Medicine and Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Type 2 diabetes (T2D) is a global health issue characterized by abnormal blood glucose levels and is often associated with excessive hepatic gluconeogenesis. Increased circulating non-essential amino acids (NEAAs) are consistently observed in individuals with T2D; however, the specific contribution of each amino acid to T2D pathogenesis remains less understood. Here, we report an unexpected role of the NEAA proline in coordinating hepatic glucose metabolism by modulating paraspeckle, a nuclear structure scaffolded by the long non-coding RNA Neat1.

View Article and Find Full Text PDF

Polyketide synthases (PKSs) are crucial multidomain enzymes in diverse natural product biosynthesis. Parrots use a type I PKS to produce a unique pigment called psittacofulvin in their feathers. In domesticated budgerigars and lovebirds, the same amino acid substitution (R644W) within malonyl/acetyltransferase (MAT) domain of this enzyme has been shown to cause the blue phenotype with no psittacofulvin pigmentation, proposing a strong evolutionary constraint on the mechanism.

View Article and Find Full Text PDF

Coralyne (COR) is a protoberberine-like isoquinoline alkaloid, and it is known for double-stranded (ds) DNA intercalation and topoisomerase inhibition. It can also sensitize cancer cells through various mechanisms. COR reduces the proliferation and migration of breast cancer cells by inhibiting the expression and activity of matrix metalloproteinase 9 (MMP9).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!