Long-term synchronized left ventricular bypass has been performed in calves using pneumatically powered pumps having a smooth lining fabricated of segmented polyurethane. Three different pump designs have been employed: a) sac pump, b) longitudinal tethered sac pump, and c) transverse tethered sac pump. Sizeable thrombi occurred in the apex of the sac and longitudinal tethered sac pumps. In the transverse tethered sac pumps, a considerably smaller thrombus was seen only at the flexion point on the inlet side of the pump. Thrombi occurred in areas of low flow velocity and were not prevented by anticoagulation or surface coating techniques. This study indicates the importance of ventricle design in the development of thrombus free pumps and suggests modifications to the present pumps to reduce or eliminate thrombus formation.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Targeting IL-20 alleviates inflammatory mechanical allodynia and reduces epidural fibrosis in post-laminectomy syndrome rat model.
Int Immunopharmacol
December 2024
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Clinical Medicine Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Antibody New Drug Research Center, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Background: Post-laminectomy syndrome (PLS) manifests as recurrent chronic back pain, with or without radiating leg pain, affecting 10-40% of patients following laminectomy. While surgical interventions can alleviate recurrent disc herniation or joint instability, medical management of PLS remains challenging due to unsatisfactory outcomes. Epidural fibrosis is a frequent cause of PLS, leading to nerve root tethering and dural sac compression.
View Article and Find Full Text PDFTethered cord prevalence among patients with prenatal or postnatal myelomeningocele repair.
Childs Nerv Syst
November 2024
Department of Neurological Surgery, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY, 10467, USA.
Article Synopsis
- - The study investigates outcomes of prenatal versus postnatal surgical repair of myelomeningocele (MMC), a severe form of spina bifida, focusing on factors like spinal cord tethering and other complications.
- - A total of 18 patients were reviewed from 2002 to 2020, with equal groups for prenatal and postnatal repair, and demographic data collected included age, sex, and medical history.
- - Results showed that patients who had prenatal closure experienced fewer detethering procedures and lower rates of requiring a ventriculoperitoneal shunt compared to those with postnatal repair, highlighting potential benefits of prenatal surgery.
Traditional pharmacology has limited control of drug activity and localization in space and time. Herein, we described an approach for kinase regulation using conditional localization pharmacology (CLP), where an inactive caged inhibitor is localized to a site of interest in a dormant state using intracellular protein tethering. The activity of the inhibitor can be regulated with spatial and temporal precision in a live cellular environment using light.
View Article and Find Full Text PDFThe WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Cell
August 2024
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China. Electronic address:
Vesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells.
View Article and Find Full Text PDFSUPPLEMENTAL DESCRIPTION OF CABALLEROTREMA ANNULATUM (DIESING, 1850) OSTROWSKI DE NÚÑEZ AND SATTMANN, 2002 (DIGENEA: CABALLEROTREMATIDAE) FROM A NEW HOST (ELECTROPHORUS CF. VARII) AND LOCALITY (AMAZON RIVER, COLOMBIA) WITH PHYLOGENETIC ANALYSIS AND EMENDED GENERIC DIAGNOSIS.
J Parasitol
July 2024
Aquatic Parasitology Laboratory and Southeastern Cooperative Fish Parasite and Disease Laboratory, School of Fisheries, Aquaculture, and Aquatic Sciences, College of Agriculture, Auburn University, 559 Devall Drive, Auburn, Alabama 36849.
Herein, we provide a supplemental description of Caballerotrema annulatum (Diesing, 1850) Ostrowski de Núñez and Sattmann, 2002 (Digenea: Caballerotrematidae Tkach, Kudlai, and Kostadinova, 2016) based on specimens collected from the intestine of an electric eel, Electrophorus cf. varii (Gymnotiformes: Gymnotidae) captured in the Amazon River (Colombia). This caballerotrematid can be differentiated from its congeners by the following combination of morphological features: body surface spines forming contiguous transverse rows, concentric (wrapping dorso-ventrally around body), distributing into posterior body half (vs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!