During human gait, cortical convergence on sural nerve reflex pathways was investigated by means of transcranial magnetic stimulation (TMS) of the cortex in five phases of the step cycle during human walking on a treadmill. Muscular responses to paired electrical and magnetic stimulation were compared with the linear summation of the individual stimuli. For both the tibialis anterior (TA) and biceps femoris (BF) muscles, the averaged data of four subjects showed a significant facilitation mainly in the swing phase of the step cycle. It is suggested that facilitation of corticospinal input onto cutaneous reflex pathways is enhanced specifically in these periods of the step cycle.
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http://dx.doi.org/10.1016/s0006-8993(97)01557-6 | DOI Listing |
BMC Genomics
January 2025
Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Background: Due to sexual dimorphism in growth of penaeid shrimp, all-female cultivation is desirable for the aquaculture industry. 17β-estradiol (E2) has the potential to induce the male-to-female sex reversal of decapod species. However, the mechanisms behind it remain poorly understood.
View Article and Find Full Text PDFSci Rep
January 2025
Nano-fabricated Energy Devices Lab, School of Electrical and Computer Eng., University of Tehran, 14395-515, Tehran, Iran.
Core-shell silicon/multiwall carbon nanotubes are one of the most promising anode candidates for further improvement of lithium-ion batteries. Sufficient accommodation for massive volume expansion of silicon during the lithiation process and preventing pulverization and delamination with easy fabrication processes are still critical issues for practical applications. In this study, core-shell silicon/MWCNTs anode materials were synthesized using a facile and controllable PECVD technique to realize aligned MWCNTs followed by a silicon sputtering step.
View Article and Find Full Text PDFPLoS One
January 2025
Center for Computation and Integrative Biology, Rutgers, The State of New Jersey, Camden, NJ, United States of America.
Melatonin, a molecule with diverse biological functions, is ubiquitously present in living organisms. There is significant interest in understanding melatonin signal transduction pathways in humans, particularly due to its critical role in regulating the sleep-wake cycle. However, a knowledge gap remains in fully elucidating the mechanisms by which melatonin influences circadian regulation.
View Article and Find Full Text PDFJ Am Podiatr Med Assoc
January 2025
¶Department of Medicine, Division of Rheumatology, Firat University, Elazig, Turkey.
Background: Many factors, such as decreased spinal mobility, pain, and dysfunction can affect gait parameters in patients with ankylosing spondylitis. The purpose of this study was to investigate the effects of plantar fascia enthesitis and disease-specific measurements on gait parameters in patients with ankylosing spondylitis.
Methods: The Win-Track platform was used to evaluate spatiotemporal parameters in patients with ankylosing spondylitis and in healthy controls.
mSystems
January 2025
Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the allosteric inactivation of pyruvate kinase, the enzyme responsible for the irreversible final step of glycolysis. Using the model bacterium as an example, we discovered that pyruvate kinase activity is inhibited during gluconeogenesis via its extra C-terminal domain (ECTD), which is essential for autoinhibition and metabolic regulation.
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