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Dynamical modelling of lipid droplet formation suggests a key function of membrane phospholipids.
FEBS J
January 2025
Institute of Biochemistry, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
Cells store triacylglycerol (TAG) within lipid droplets (LDs). A dynamic model describing complete LD formation at the endoplasmic reticulum (ER) membrane does not yet exist. A biochemical-biophysical model of LD synthesis is proposed.
View Article and Find Full Text PDFElasto-morphology of P3HT:PCBM bulk heterojunction organic solar cells.
Soft Matter
August 2020
Department of Mechanical Engineering & Mechanics, Lehigh University, Packard Laboratory 561, 19 Memorial Drive West, Bethlehem, PA 18015, USA.
Predicting the mechanical properties of organic semiconductors is important when using these materials in flexible electronics applications. For instance, knowledge of the mechanical and thermal stability of thin film organic solar cells (OSCs) is critical for the roll-to-roll production of photovoltaic devices and their use under various operating conditions. Here, we examine the thermal and elasto-mechanical properties of the conjugated donor polymer poly-(3-hexylthiophene) (P3HT) and the interpenetrating mixtures of P3HT and phenyl-C-butyric acid methyl (PCBM) ester bulk heterojunction (BHJ) active layers under the application of unidirectional tensile deformation using coarse-grained molecular dynamics (CGMD) simulations.
View Article and Find Full Text PDFCompliance mismatch and compressive wall stresses drive anomalous remodelling of pulmonary trunks reinforced with Dacron grafts.
J Mech Behav Biomed Mater
October 2016
Department of Structures for Engineering and Architecture and Interdisciplinary Research Center for Biomaterials, University of Napoli Federico II, Italy. Electronic address:
Synthetic grafts are often satisfactory employed in cardiac and vascular surgery, including expanded poly(ethylene terephthalate) or expanded poly(tetrafluoroethylene). However, accumulating evidences suggest the emergence of worrisome issues concerning the long-term fate of prosthetic grafts as large vessel replacement. Disadvantages related to the use of synthetic grafts can be traced in their inability of mimicking the elasto-mechanical characteristics of the native vascular tissue, local suture overstress leading to several prosthesis-related complications and retrograde deleterious effects on valve competence, cardiac function and perfusion.
View Article and Find Full Text PDFCharacterization of Ta and TaN diffusion barriers beneath Cu layers using picosecond ultrasonics.
Ultrasonics
December 2006
Center of Mechanics, ETH Zurich, 8092 Zurich, Switzerland.
In computer chips, aluminum is being replaced with copper in order to produce smaller, faster and more efficient electronic devices. The usage of copper allows higher current densities and thus higher packaging densities than aluminum. However, copper leads to new challenges and problems.
View Article and Find Full Text PDFNanomedicine and protein misfolding diseases.
Nanomedicine
December 2005
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, Nebraska 68198-6025, USA.
Misfolding and self assembly of proteins in nano-aggregates of different sizes and morphologies (nano-ensembles, primarily nanofilaments and nano-rings) is a complex phenomenon that can be facilitated, impeded, or prevented, by interactions with various intracellular metabolites, intracellular nanomachines controlling protein folding and interactions with other proteins. A fundamental understanding of molecular processes leading to misfolding and self-aggregation of proteins involved in various neurodegenerative diseases will provide critical information to help identify appropriate therapeutic routes to control these processes. An elevated propensity of misfolded protein conformation in solution to aggregate with the formation of various morphologies impedes the use of traditional physical chemical approaches for studies of misfolded conformations of proteins.
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